Denigma

shk-1 mutation

Species: Nematode (Taxid: 6239)
Factor: shk-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutation of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants [22768380].

Mutation of shk-1 enhances pheromone-induced dauer formation [22768380].

Mean: +19 to 22
Maximum: +20 to 24

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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