unc-17 mutation

Species: Nematode (Taxid: 6239)
Factor: unc-17
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. unc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].

Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].

Mean: +31 to +79
Maximum: +68 to +79

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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