Denigma

aak-2 constitutive active mutation

Species: Nematode (Taxid: 6239)
Factor: aak-2
Manipulation: Gain-of-Function, Mutation
Effect:

A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi [17900900].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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