CYR1 mutation

Species: Budding yeast (Taxid: 4932)
Factor: CYR1
Manipulation: Loss-of-Function, Mutation
Effect:

The CDC35-1 allele of the adenylate cyclase CYR1 confers a 75% extension of replicative lifespan at 25 degree Celsius [11000115]. cyr1-1 mutation extends median chronological lifespan by 28-47% and is non-addative with lifespan extension conferred by overxpression of human MAPK1 [17662940].

Mean: +75
Median: +28 to 47

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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