Denigma

TSA1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: TSA1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Disruption of TSA1 shortens chronological lifespan [15129730]. Replicative lifespan extension by DR in sir2;fob1 double mutant is reduced by TSA1 deletion mutant. Wild-type cells require TSA1 to fully extend lifespan. Mutation in CDC35 (adenylate cyclase), a genetic mimetic of DR, is dependent on TSA1 to extend lifespan [21884982].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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