Denigma: Intervention

TCO89 deletion

Species: Budding yeast (Taxid: 4932)
Factor: TCO89
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

TCO89 deletion increases chronological lifespan, increases mitochondrial oxygen consumption, but decreases mitochondrial and cellular ROS in early stationary phase [21641548]. Deletion of TCO89 cancels out replicative lifespan extension by moderate DR [18690010].

Aging Relevance Analysis/Source:

GenAge