HHF1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HHF1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

HHF1 deletion extends mean and maximum replicative by 45 and 69%, respectively, as well as chronological lifespan. Chronological lifespan extension by HHF1 deletion and DR is non-synergistic. DR appears to extend replicative lifespan more when combined with hhf1 mutation, whereas DR does not change hhf1-induced replicative lifespan extension, suggesting a positive interaction [21584246].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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