Denigma

HSP12 deletion

Species: Budding yeast (Taxid: 4932)
Factor: HSP12
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

HSP12 deletion slightly increases mean, medium, and maximum replicative lifespan by 24, 27, and 3% under AL, but totally abolishes the lifespan extending effect of moderate DR [Alan Morgan, personal communication; Herbert et al. in press].

HSP12 deletion has no effect on resistance to variety of stresses (including oxidative stress) [Alan Morgan, personal communication].

Mean: +24
Median: +27
Maximum: +3

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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