Denigma

PCK1 mutation

Species: Budding yeast (Taxid: 4932)
Factor: PCK1
Manipulation: Loss-of-Function, Mutation
Effect:

pck-1-K514Q mutation which abrogates enzymatic activity of Pck1, just like SIR2 deletion, extends chronological lifespan in water. Deletion of SIR2 does not alter the lifespan of PCK1 deletion mutant, pck1-K514R, and pck1-K514Q mutants [19303850].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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