Lep knockout

Species: House mouse (Taxid: 10090)
Factor: Lep
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Lep knockout results in ob/ob mice which eats excessively and becomes profoundly obese. ob/ob mice live shorter on ad libitum, but achieve a lifespan similiar to control levels under DR, yet their precentage of body fat is much greater that that of controls [6608731].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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