| dcp-66 | Deacetylase Complex Protein 66 | dcp-66 RNAi shortens the mean lifespan by 29% and suppresses lifespan extension by isp-1 mutation, but does not significantly affect lifespan extension neither by eat-2 nor daf-2 mutation [22829775]. | Nematode |
| sodh-1 | SOrbitol DeHydrogenase family 1 | RNA interference of sodh-1 does not affect the lifespan of eat-2 mutants, although SODH-1 is elevated in eat-2 mutants [22810224]. | Nematode |
| CLEC-63 | C-type LECtin 63 | RNA interference of clec-63 has no significant effect on the lifespan of eat-2 mutants, although CLEC-63 is elevated in eat-2 mutants [22810224]. | Nematode |
| cyc-2.1 | CYtochrome C 2.1 | RNA interference of cyc-2.1 increases mean lifespan by 80% [17608836]. cyc-2.1 RNAi has no significant effect on lifespan of eat-2 mutants, although CYC-2.1 levels are elevated in eat-2 mutants [22810224]. | Nematode |
| asp-3 | ASpartyl Protease 3 | RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi. ASP-3 is upregulated in eat-2 mutants [22810224]. | Nematode |
| icl-1 | IsoCitrate Lyase homolog 1 | RNAi knockdown of icl-1 (alias gei-7) starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Nematode |
| acdh-12 | Acyl CoA DeHydrogenase 12 | RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. | Nematode |
| hpd-1 | 4-HydroxyPhenylpyruvate Dioxygenase (HPD)) 1 | RNAi knockdown of hpd-1 starting at hatching or only during the adulthood significantly extends lifespan of both wild-type and eat-2 [22810224]. | Nematode |
| fat-2 | FATty acid desaturase 2 | RNAi knockdown of fat-2 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants. FAT-2 is downregulated in eat-2 [22810224].
| Nematode |
| pod-2 | Polarity and Osmotic sensitivity Defect 2 | RNA interference of pod-2 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. POD-2 is downregulated in eat-2 [22810224]. | Nematode |
| acdh-1 | Acyl CoA DeHydrogenase 1 | RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| pck-1 | Phosphoenolpyruvate CarboxyKinase 1 | RNA interference of pck-1 during the adulthood significantly shortens lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pck-1 from hatching cases larval lethality. Overexpression of pck-1 greatly increases content of PEPCK-C, markedly induces enzyme activity and significantly increases mean, 75%ile, and maximum lifespan by 19-23%, 17-22%, and 21% [22810224]. | Nematode |
| pyc-1 | PYruvate Carboxylase 1 | RNA interference of pyc-1 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. PYC-1 is downregulated in eat-2 mutants [22810224]. | Nematode |
| pyk-1 | PYruvate Kinase 1 | RNA interference of pyk-1 during adulthood significantly shortens the lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pyk-1 from hatching causes larval lethality. PYK-1 is downregulated in eat-2 mutants [22810224].
pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment [20974969]. | Nematode |
| enol-1 | ENOLase 1 | RNA interference of enol-1 during adulthood significantly shortens the lifespan of both wild-type and eat-2 mutants. RNAi knockdown of enol-1 from hatching causes larval lethality.
ENOL-1 downregulated in eat-2 mutants [22810224]. | Nematode |
| tps-2 | Trehalose 6-Phosphate Synthase 2 | RNA interference mediated inactivation of the trehalose-biosynthetic gene trehalose-6-phosphate synthase-2 (tps-2) decreases daf-2 mutant's long lifespan [20477758]. | Nematode |
| tps-1 | Trehalose 6-Phosphate Synthase 1 | RNA interference mediated inactivation of the trehalose-biosynthetic gene trehalose-6-phosphate synthase-1 (tps-1) decreases daf-2 mutant's long lifespan [20477758]. | Nematode |
| let-4 | LEThal 4 | let-4 (alias sym-5) is downregulated in space.
RNA intereference of let-4 extends mean and 75%ile lifespan by 4%, but reduces maximum lifespan by 25% [22768380]. | Nematode |
| ins-35 | INSulin related 35 | ins-35 encodes an insulin-like peptide which is downregulated in space. Mutation or RNA interference of ins-35 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. ins-35 RNAi extends mean, 75%ile, and maximum lifespan by 8, 4, and 32%. ins-35(TM290) mutation extends mean, 75%ile, and maximum lifespan by 15-17, 14-23, and 23-24%. Lifespan extension by ins-35 mutation is totally abolished by daf-16 or skn-1 RNAi inactivation eat-2 RNAi further enhances the extension of lifespan by mutation in ins-35 [22768380].
Mutation and RNAi of ins-35 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| shk-1 | SHaKer family of potassium channels 1 | shk-1 encodes a shaker family of potassium channel which functions in muscle [21059759], is expressed in sensory neurons [16899454], and downregulated in space. Mutation or RNA interference of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1 RNAi extends mean, 75%ile, and maximum lifespan by 16, 15, and 22%. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants. RNAi inactivation of shk-1 reduces Q35 aggregation [22768380].
Mutation and RNAi of shk-1 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| glc-4 | Glutamate-gated ChLoride channel 4 | glc-4 encodes a glutamate-gated chloride channel which is expressed in sensory neurons [17850180] and is downregulated in space. Mutation or RNA interference of glc-4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. glc-4 RNAi extends the mean, 75%ile, and maximum lifespan by 13, 11, and 19%. glc-4(JD31) increases the mean, 75%ile, and maximum lifespan by 13-23, 11-23, 19-34%. Lifespan extension by glc-4 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi further enhances the extension of lifespan by glc-4 mutation [22768380].
Mutation and RNAi of glc-4 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| F57A8.4 | Protein F57A8.4 | F57A8.4 encodes a rhodopsin-like G-protein coupled receptor that is known to sense light [11493519] and is downregulated in space.
Mutation or RNA interference of F57A8.4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. F57A8.4 RNAi extends the mean, 75%ile and maximum lifespan by 34, 39, and 61%. F57A8.4(tm4341) mutation extends the mean, 75%ile, and maximum lifespan by 18-38, 21-25, and 42-68%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of either daf-16 nor skn-1. eat-2 RNAi shortens the lifespan of F57A8.4 mutants [22768380].
Mutation and RNAi of F57A8.4 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| cha-1 | abnormal CHoline Acetyltransferase 1 | cha-1 encodes a choline acetyltransferase which is expressed in motor [18041778] neurons and downregulated in space. Mutation or RNA interference of cha-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium [22768380]. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants. RNAi inactivation of cha-1 reduces Q35 aggregation [22768380].
cha-1 participates in determining pharyngeal pumping rate to affect food intake [6698395]. | Nematode |
| unc-17 | UNCoordinated 17 | unc-17 encodes acteylcholine transporter which is expressed in motor [18041778] and inter-neurons and is downregulated in space. Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. nc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| gar-3 | G-protein-linked Acetylcholine Receptor 3 | gar-3 encodes a acetycholine receptor which is expressed in motor neurons and muscle [17287516], participates in acetylcholine transmission in motor neuron-muscle signalling, and is downregulated in space. Mutation or RNA interference of gar-3 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. gar-3 RNAi extends mean, 75%ile, and maximum lifespan by 11, 14 an 17%. gar-3(VC670) mutation extends mean, 75%ile, and maximum lifespan by 5-18, 4-7 and 15-56%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of daf-16, skn-1, or eat-2. RNAi inactivation of gar-3 reduces Q35 aggregation [22768380]. | Nematode |
