Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 ADAMTS6 was found to be associated with longevity [22445811]. Human
    ADARB1 adenosine deaminase, RNA-specific, B1 ADARB1 was found to be associated with longevity [20011587]. Human
    ADARB2 adenosine deaminase, RNA-specific, B2 ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. Human
    ADCY2 adenylate cyclase 2 (brain) ADCY2 was found to be associated with longevity [19641380]. Human
    ADCY5 adenylate cyclase 5 ADCY5 was not found to be associated with longevity [23020224]. Human
    ADCY6 adenylate cyclase 6 ADCY6 was found to be associated with longevity [23020224]. Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ10 adiponectin, C1Q and collagen domain containing ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. Human
    ADIPQO adiponectin, C1Q and collagen domain containing ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. Human
    ADRB1 adrenergic, beta-1-, receptor ADRB1 was not found to be associated with longevity [23020224]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    AFX forkhead box O4 AFX was not found to be associated with longevity [19489743]. Human
    AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) M/T235 SNP in the AGT gene was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) and a significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele [11602206].AGT was found to be associated with longevity [15621215]. AGT was found to be associated with longevity [11602206]. AGT was not found to be associated with longevity [15621215]. Human
    AGTR1 angiotensin II receptor, type 1 AGTR1 was found to be associated with longevity [22569962]. AGTR1 was not found to be associated with longevity [22569962]. Human
    AIF1 allograft inflammatory factor 1 AIF1 was found to be associated with longevity [22279548]. Human
    AKAP10 A kinase (PRKA) anchor protein 10 Male (n= 4766) and female (n = 6202) divided into young (183-9 years) and old (60 years) groups were examined for polymorphisms. A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females [12646697]. Human
    AKT1 v-akt murine thymoma viral oncogene homolog 1 AKT1 was found to be associated with longevity [19489743]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was not found to be associated with longevity [22929028]. Human
    AKT2 v-akt murine thymoma viral oncogene homolog 2 AKT2 was not found to be associated with longevity [19489743]. Human
    AKT3 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) AKT3 was not found to be associated with longevity [19489743]. Human
    ALDH2 (for males) aldehyde dehydrogenase 2 family (mitochondrial) ALDH2 (for males) was found to be associated with longevity [19641380]. Human
    ANGEL1 angel homolog 1 (Drosophila) ANGEL1 was found to be associated with longevity [22279548]. Human
    ANK2 ankyrin 2, neuronal ANK2 was found to be associated with longevity [22445811]. Human
    Factors are an extension of GenAge and GenDR.

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