Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    GSTM1 glutathione S-transferase mu 1 GSTM1 was not found to be associated with longevity [11162685]. Human
    INS insulin INS was not found to be associated with longevity [19367319]. Human
    SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 SLC6A4 was found to be associated with longevity [15621215]. Human
    TAS2R16 taste receptor, type 2, member 16 TAS2R16 was found to be associated with longevity [23133589]. Human
    TUBB4B tubulin, beta 2C TUBB4B was found to be associated with longevity [22174011]. Human
    16S rRNA 16S rRNA was found to be associated with longevity [10996007]. Human
    3p22-24 region 3p22-24 region was found to be associated with longevity [22506048]. Human
    3p24-22 3p24-22 was found to be associated with longevity [20824210]. Human
    5HTT solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 5HTT was found to be associated with longevity [16095668]. Human
    6q25-27 region 6q25-27 region was found to be associated with longevity [22773346]. Human
    AAT serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 AAT was found to be associated with longevity [17048073]. AAT was found to be associated with longevity [17048073]. Human
    ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 The R219K SNP was examined in 256 centenarians and 190 healthy younger controls. The allelic frequency were not different between the two groups [12601526]. Human
    ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 ABCA7 was not found to be associated with longevity [22445811]. Human
    ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 ABCC4 was found to be associated with longevity [22533364]. Human
    ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ABCC8 was not found to be associated with longevity [21612516]. Human
    ABL1 c-abl oncogene 1, non-receptor tyrosine kinase ABL1 was found to be associated with longevity [22445811]. Human
    AC000050.2 AC000050.2 was found to be associated with longevity [22533364]. Human
    ACCN1 amiloride-sensitive cation channel 1, neuronal ACCN1 was found to be associated with longevity [22279548]. Human
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE was found to be associated with longevity [12954489]. Human
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE was not found to be associated with longevity [12634288]. Human
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829]. I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559]. I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238]. I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214]. Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. Human
    ACE1 angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE1 was found to be associated with longevity [12954489]. Human
    ACPL2 acid phosphatase-like 2 ACPL2 was found to be associated with longevity [22445811]. Human
    ACTN3 actinin, alpha 3 ACTN3 was not found to be associated with longevity [21407828]. Human
    ADA adenosine deaminase ADA was found to be associated with longevity [20174870]. ADA was found to be associated with longevity [21865054]. Human
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    • 25 of 724 factors
    Factors are an extension of GenAge and GenDR.

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