| CG12016 | — | CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12090 | — | CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG12576 | — | CG12576 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG13306 | — | CG13306 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG13890 | — | Overexpression of CG13890 (DCI) throughout the whole body increases mean and median lifespan by 35 and 31%, but decreases maximum lifespan by 6%, increases stress resistant (to paraquat and starvation), consistently reduces the mortality rate across adult ages and reduces the lifespan extension of DR by 15% [22997544].
CG6783 overexpression increases the dFOXO nuclear localization in the fat-body. mRNA levels of dFOXO target genes l(2)efl and 4E-BP in the adult whole bodies increases in response to overexpression of CG6783 [22997544]. | Fruit fly |
| CG13917 | — | CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG16711 | — | CG16711 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG16718 | — | CG16718 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
| CG17856 | — | RNAi of CG17856 results in an increase in mean lifespan of 13-18% in females. In the case of males and post-developmental experiments the results are variable [19747824]. | Fruit fly |
| CG18809 | — | RNAi of CG18809 results in a 7-19% increase in mean lifespan of females, while neural RNAi results in an increased mean lifespan of up to 12% in females. For males the results are variable [19747824]. | Fruit fly |
| CG30427 | — | Overexpression of CG30427 in males increases mean lifespan by 18% [22366109]. | Fruit fly |
| CG32022 | — | CG32022 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG33138 | — | Overexpression of CG33138 in males increased mean lifespan by 11% [22366109]. | Fruit fly |
| CG34243 | — | CG34243 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG34426 | — | CG34426 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG3776 | — | Both overexpression and underexpression of CG3776 (alias Jhebp29) reduces the mean lifespan, where the reduction in males is slightly higher.
The lifespan of male flies with under- and overexpressed CG3776 is reduced by 38.8 and 42.6%, respectively when compared with Oregon R flies.The lifespan of female flies with under- and overexpressed CG3776 is reduced by 31.6 and 35%, respectively when compared to Oregon R flies.
Among the males and females, relatively to Oregon R and EP835/CyO, the age-specific survival of EP835/EP835 and EP835/Gal4 is reduced in both log-rank and Wilcoxon tests (P < 0.001); survival of EP835/EP835 and EP835/Gal4 differed using the log-rank-test (male: P<0.001; female: P=0.027) [18275960].
| Fruit fly |
| CG42663 | Odorant-binding protein 49a | Overexpression of CG42663 in males increases mean and maximum lifespan by 18% and 7% [22366109]. | Fruit fly |
| CG4389 | CG4389 gene product from transcript CG4389-RA | Muscle specific RNAi knockdown of CG489 which reduces its mRNA levels by 25-35%, significantly reduces the DR-dependent lifespan extension. CG4389 RNAi animals exhibit only 20% increase while controls display an lifespan increase by 123% upon DR [22768842]. | Fruit fly |
| CG4726 | — | CG4726 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG4942 | — | CG4942 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG5194 | — | CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
| CG5389 | — | RNAi of complex V subunit CG5389 results in increased mean longevity under standard laboratory food conditions (3% yeast) in males. RNAi started from the development results in a mild lifespan increase in both sexes (3-11% in females and 3-8% in males). Post-developmental RNAi and silencing limited to neurons has variable effects with reduction in lifespan of up to 9% [19747824]. Under rich media conditions CG5389 knockdown throughout development and adulthood increases mean lifespan by 26% and abolished the lifespan extension by DR (started in the adulthood) in males. Suppression of CG5389 only during the adulthood either via RNAi by tub-GS or via oligomycin (a specific inhibitor of complex V) feeding prevents an increase in longevity under DR (started in the adulthood) in males [19968629]. | Fruit fly |
| CG6041 | — | CG6041 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6048 | — | CG6048 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6184 | — | CG6184 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
