| bar-1 | beta-catenin | BAR-1 may play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress as it directly interaction with DAF-16 and loss of bar-1 reduces activity of DAF-16 in dauer formation and lifespan. Deletion of bar-1 reduces mean (44%) and maximal (18%) lifespan, which is to a similar degree as seen to daf-16 mutants [15905404]. SMK-1 is important DAF-16 modulation of lifespan and specific stress response [5]. | Nematode |
| bec-1 | BEClin (human autophagy) homolog 1 | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Nematode |
| blmp-1 | Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog 1 | RNA interference of blmp-1 decreases median lifespan by 17% in a daf-2 background and 20% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| BNA6 | Biosynthesis of Nicotinic Acid 6 | Deletion of BNA6 (alias QPT1) has no effect on replicative lifespan and is not required for lifespan extension by DR, but is lethal with mutation of NPT1 [11000115]. Deletion of BNA6 decreases chronological lifespan [17110466]. | Nematode |
| bra-1 | BMP receptor Associated protein family | bra-1(nk1) mutation reduces mean lifespan by 6-25% [17900898]. | Nematode |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| bus-8 | Bacterially Un-Swollen (M. nematophilum resistant) 8 | RNA interference of tag-249 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C01F1.1 | — | RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C06A5.1 | — | RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C07A9.2 | — | RNA interference of C07A9.2 decreases median lifespan by 26% in wild type animals, 37% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C09B7.2 | transposase | RNA interference of C09B7.2 extends lifespan [15998808]. | Nematode |
| C11H1.3 | — | RNA interference of C11H1.3 decreases median lifespan by 10% in wild type animals, 14% in a daf-2 background and 41% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C14A4.11 | Cell-death-Related Nuclease | C14A4.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| C14A4.14 | mammalian cell Death Associated Protein related | C14A4.14 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| C14A4.9 | — | RNA interference of C14A4.9 decreases median lifespan by 14% in wild type animals and 41% in daf-2 mutants [18006689]. | Nematode |
| C16C10.2 | CCDC (human Coiled Coil Domain Containing) homolog | C16C10.2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| C18E9.10 | — | RNA interference of C18E9.10 results in lifespan extension [15998808]. | Nematode |
| C18E9.4 | — | RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. | Nematode |
| C26B2.2 | — | C26B2.2 knockout mutations extend lifespan [15253933]. | Nematode |
| C26B9.3 | — | RNA interference ofC26B0.3 decreases median lifespan by 12% in wild type animals, 68% in a daf-2 background and 17% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C27B7.7 | — | RNA interference of C27B7.7 extends lifespan [15998808]. | Nematode |
| C29F9.1 | — | RNA interference of C29F9.1 decreases median lifespan by 35% in daf-2 mutants [18006689]. | Nematode |
| C29F9.2 | — | RNA interference of C29F9.2 decreases median lifespan by 12% in wild type animals and 36% in daf-2 mutants [18006689]. | Nematode |
| C32H11.1 | — | RNA interference of C32H11.1 extends lifespan [12845331]. | Nematode |
| C32H11.5 | — | RNA interference of C32H11.5 extends lifespan [15998808]. | Nematode |
