| aph-2 | Anterior PHarynx defective | aph-2 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| apr-1 | APC Related | — | Nematode |
| aps-1 | AdaPtin, Small chain (clathrin associated complex) 1 | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Nematode |
| aqp-1 | AQuaPorin or aquaglyceroporin related 1 | aqp-1 expression changes in response to glucose or glycerol. Similar to daf-16 and hsf-1 mutants, aqp-1 mutants were short-lived, and their short lifespan was not further decreased by glucose. Overexpression of aqp-1::GFP rescues short lifespan of aqp-1 deletion mutants and partially prevented glucose from shortening lifespan. Glucose or glycerol feeding downregulates aqp-1 in wild-type. In daf-16 and/or hsf-1 mutants aqp-1 is repressed and glucose feeding does not significantly affect its expression. aqp-1 mutation does not further decrease the short lifespan of daf-16 and/or hsf-1 mutants. aqp-1 transgene is expressed in pharynx and intestine (which behaves as entire endoderm of animal, including adipose tissues). Dietary glucose does not cause significant differences in levels of glucose or glycerol in wild-type vs. aqp-1 mutants [19883616]. | Nematode |
| arl-8 | ARF-Like 8 | RNA interference of arl-8 decreases median lifespan by 35% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| arx-4 | ARp2/3 compleX component 4 | RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| asb-1 | ATP Synthase B homolog | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Nematode |
| asb-2 | ATP Synthase B homolog 2 | RNA interference of abs-2 leads to lifespan extension [16103914]. | Nematode |
| asg-1 | ATP Synthase G homolog 1 | RNA interference of asg-1 leads to lifespan extension [15998808]. | Nematode |
| asg-2 | ATP synthase subunit 2 | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Nematode |
| Ash-2 | — | RNAi extended fertile lifespan. | Nematode |
| asm-3 | Acid SphingoMyelinase 3 | RNA interference of asm-3 increases mean lifespan by 50% [17608836]. | Nematode |
| asp-3 | ASpartyl Protease 3 | RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi. ASP-3 is upregulated in eat-2 mutants [22810224]. | Nematode |
| atg-7 | AuTophaGy (yeast Atg homolog) 7 | RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg7 RNAi does not affect lifespan of wild-type, but totally cancels out the lifespan extension effect of eat-2 mutation [17912023]. | Nematode |
| atp-2 | ATP synthase F1 subunit gamma 2 | RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594]. | Nematode |
| atp-3 | ATP synthase subunit | RNA interference against atp-3 results in lifespan extension [16103914]. atp-3 RNAi increases lifespan by 46% (mean by 33 and maximum by 70%). RNAi of atp-3 during larval stage is necessary and sufficient for lifespan prologation, while atp-3 RNAi only during the adulthood fails the extend lifespan. atp-3 RNAi results in reduced pharageal pumping, defection and motility as well as ATP levels and body size [12471266]. | Nematode |
| atp-4 | ATP synthase subunit 4 | RNA interference of atp-4 results in lifespan extension [16103914]. | Nematode |
| atp-5 | ATP synthase subunit 5 | RNA interference of atp-5 results extended lifespan [16103914]. | Nematode |
| B0035.12 | — | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Nematode |
| B0280.9 | Nuclear Hormone Receptor family | B0280.9 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| B0393.6 | F-box A protein | B0393.6 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| B0491.5 | — | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Nematode |
| B0511.6 | — | RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. | Nematode |
| B0546.3 | — | RNA interference of B0546.3 increases mean lifespan by 27% [17608836]. | Nematode |
| baf-1 | Barrier to Autointegration Factor 1 | RNA interference of baf-1 decreases median lifespan by 28% in daf-2 mutants [18006689]. | Nematode |
