Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    (-)-epidcatechin Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. Nematode
    aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 aak-1 does not appear to be required for the control of lifespan [15574588]. Nematode
    aak-2 AMP-Activated Kinase 2 AAK-2 could be a sensor that couples energy levels and insulin-like signals to lifespan. aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. sDR increases AMP:ATP ratio. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR. A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi. sod-3 mRNA is increased by constitutive active form of aak-2 and decreased by aak-2 mutation. The increase in sod-3 mRNA is dependent on expression of DAF-16. Worm and human AMPK phosphorylate DAF-16 (greatly enhanced by presence of AMP) at least in six residues (T166, S202, S314, S321, T463 and S466) [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant. Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. Nematode
    aakb-1 AMP-Activated Kinase Beta subunit 1 RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Nematode
    aakb-2 AMP-Activated Kinase Beta subunit 2 RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. Nematode
    aakg-2 AMP-Activated protein Kinase Gamma subunit 2 aakg-2 overexpression extends mean, median, and maximum lifespan by 47, 45, and 35%. Overexpression of aakg-2 toegther with D. rerio ucp2 was non-additive with sDR [22737090]. Nematode
    aat-8 Amino Acid Transporter 8 RNA interference of aat-8 increases mean lifespan by 30% [17608836]. Nematode
    abce-1 ABC transporter, class E abce-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Nematode
    abcx-1 ABC transporter, eXtended 1 RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. Nematode
    abi-1 ABl Interactor homolog abi-1 RNAi in the adulthood extends the lifespan [New longevity regulators]. Nematode
    abu-11 Activated in Blocked Unfolded protein response 11 Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. Nematode
    acdh-1 Acyl CoA DeHydrogenase 1 RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. Nematode
    acdh-12 Acyl CoA DeHydrogenase 12 RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. Nematode
    acl-11 ACyLtransferase-like 11 RNA interference of acl-11 leads to lifespan extension [12447374]. Nematode
    aco-2 ACOnitase RNA interference of aco-2 leads to lifespan extension [15998808]. Nematode
    acs-5 fatty Acid CoA Synthetase family 5 RNA interference of acs-5 increases mean lifespan by 52% [17608836]. Nematode
    age-1 AGEing alteration 1 Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740]. RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672]. age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. age-1 RNAi and mutation extend lifespan by 30% and 100%, respectively [8700226; 8608934]. Nematode
    age-2 Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. Nematode
    agmo-1 AlkylGlycerol MonoOxygenase 1 RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. Nematode
    ain-1 ALG-1 INteracting protein 1 RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. Nematode
    akt-1 AKT kinase family 1 RNA interference of akt-1 leads to lifespan extension [15998808]. Nematode
    alg-1 Argonaute (plant)-Like Gene Adult-specific knockdown of the C. elegans argonaute-like gene 1 alg-1 results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. Nematode
    alg-2 Argonaute (plant)-Like Gene 2 RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. Nematode
    amt-2 AMmonium Transporter homolog 2 RNA interference of amt-2 increases mean lifespan by 20% [17608836]. Nematode
    ant-1.1 Adenine Nucleotide Translocator 1.1 RNA interference of ant-1.1 increases mean lifespan by 40% [17608836]. Nematode
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    • 25 of 864 factors
    Factors are an extension of GenAge and GenDR.

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