| — | Hesperidin | Hesperidin derived from the Citrus genus extends replicative lifespan at doses of 5 and 10 microMolar. Hesperdin inihibts ROS and UTH1 gene expression, but increases Sir2 and SOD gene expression. UTH1 and SKN7 are involved in lifespan extension mediated by hesperidin [22484922]. | Budding yeast |
| AAC3 | Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration | Replicative lifespan increased by 15% in the alpha strain | Budding yeast |
| AAT1 | Aspartate AminoTransferase 1 | Overexpression of AAT1 extends replicative lifespan by 25% and does not synergize with 0.5% glucose restriction [18381895]. | Budding yeast |
| AAT2 | Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells | Replicative lifespan increased by 15% | Budding yeast |
| ABP1 | Actin Binding Protein 1 | ABP1 deletion increases replicative lifespan by 30% in the alpha strain and decreases replicative lifespan by 20% in the a strain [18340043]. Deletion of ABP1 increases replicative lifespan by 20% in the alpha strain and decreases replicative lifespan by 20% in the a strain [19030232]. | Budding yeast |
| ACB1 | Acyl-CoA-Binding 1 | ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825]. | Budding yeast |
| ACH1 | Acetyl CoA Hydrolase 1 | ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872]. | Budding yeast |
| ACO1 | ACOnitase 1 | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Budding yeast |
| ACO2 | ACOnitase 2 | Deletion of ACO2 increases replicative lifespan by 20% in the alpha strain and decreases it by 10% in the a strain [18340043]. Its deletion increases mean chronological lifespan by 6 - 44% (6, 22, 20, 20, 19, 44) in diploid cells [21447998]. | Budding yeast |
| ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions | Replicative lifespan decreased by 70% in the alpha strain | Budding yeast |
| ACT | ACTin | An ACT1 allele which reduces actin dynamics decreases chronological lifespan, while an allele that increases actin dynamics increases chronological lifespan by 32% [15024029]. | Budding yeast |
| ADA2 | Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes | Replicative lifespan decreased by 50% in the alpha strain | Budding yeast |
| ADE3 | ADEnine requiring 3 | Deletion of ADE3 increases chronological lifespan [20421943]. | Budding yeast |
| ADE4 | ADEnine requiring 4 | ade4 mutation extends chronological lifespan, but not replicative lifespan, and is non-additive with 0.5% glucose or amino-acid DR on chronological lifespan extension. ADE4 deletion in atg16 mutants results only in a partial extension of the chronological lifespan by 0.5% glucose DR [20421943]. | Budding yeast |
| ADH1 | Alcohol DeHydrogenase 1 | Deletion of ADH1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. Adh1 is oxidatively modified during aging and its activity becomes reduced. Overexpression of ADH1 by introducing and extra copy increases mean replicative lifespan by 30% as well as slightly chronological lifespan and was associated with increased Sir2 activity [17975074]. | Budding yeast |
| ADH2 | Alcohol DeHydrogenase 2 | Deletion of ADH2 increases mean chronological lifespan by 6 - 57% (6, 17, 57) in diploid cells [21447998]. | Budding yeast |
| ADH3 | Alcohol DeHydrogenase 3 | Deletion of ADH3 decreases mean chronological lifespan by 15% [21447998]. | Budding yeast |
| ADR1 | Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization | Replicative lifespan decreased by 35% in the alpha strain | Budding yeast |
| AFG3 | ATPase Family Gene 3 | Deletion of the mitochondrial AAA protease AFG3 increases replicative lifespan by 20% in the alpha and a strains [18340043], but decreases chronological lifespan by 37 - 51% in diploid cells [21447998].
AFG3 deletion changes mean, median and maximum lifespan by 15 to 26% 17 to 30% and -25 to +58%, respectively.
AFG3 deletion leads to reduced cytoplasmic mRNA translation and its lifespan extension is independent of Sir2 and Hac1, but requires Gcn4. AFG3 deletion further extends the lifespan of cell deficient in both SIR2 and FOB1, but fails to extend the lifespan of dietary restricted cells or cells lacking GCN4. Gcn4 protein levels are increased in afg3 mutants. The deletion of AFG3 fails to extend the replicative lifespan in the W303AR strain. AFG3 deletion does deletion extend the replicative lifespan at 15°C. | Budding yeast |
| AGC1 | Aspartate-Glutamate Carrier | Deletion of AGC1 increases replicative lifespan by 30% in the alpha strain [18340043] and increases mean chronological lifespan by 7 - 28% [21447998]. | Budding yeast |
| AGP1 | high-Affinity Glutamine Permease 1 | Deletion of AGP1 extends chronological lifespan [16418483]. | Budding yeast |
| AIM4 | Altered Inheritance rate of Mi 4 | AIM4 (alias SOY1) deletion increases chronological and replication lifespan, which is non-additive with DR. On AL mean and maximum replicative lifespan are extended by 63 and 69%, respectively. DR appears to decrease aim4-induced replication lifespan extension, indicating a negative interaction. aim4 mutation does not change DR-induced chronological lifespan extension [21584246]. | Budding yeast |
| AKL1 | Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization | Replicative lifespan increased by 20% in the alpha strain | Budding yeast |
| AKR1 | AnKyrin Repeat-containing protein 1 | Deletion of AKR1 decreases replicative lifespan by 40% in the alpha strain [18340043]. Replicative lifespan decreased by 50% in the alpha strain [19030232]. | Budding yeast |
| ALG12 | Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation | Replicative lifespan increased by 25% in the alpha strain and 25% in the a strain | Budding yeast |
