| aak-2 | AMP-Activated Kinase 2 | AAK-2 could be a sensor that couples energy levels and insulin-like signals to lifespan. aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. sDR increases AMP:ATP ratio. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR. A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi. sod-3 mRNA is increased by constitutive active form of aak-2 and decreased by aak-2 mutation. The increase in sod-3 mRNA is dependent on expression of DAF-16. Worm and human AMPK phosphorylate DAF-16 (greatly enhanced by presence of AMP) at least in six residues (T166, S202, S314, S321, T463 and S466) [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant. Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. | Nematode |
| aakb-1 | AMP-Activated Kinase Beta subunit 1 | RNA interference of aakb-1 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. | Nematode |
| aakb-2 | AMP-Activated Kinase Beta subunit 2 | RNA interference of aakb-2 results in decreased lifespan and earlier accumulation of lipofuscin [16673436]. | Nematode |
| aakg-2 | AMP-Activated protein Kinase Gamma subunit 2 | aakg-2 overexpression extends mean, median, and maximum lifespan by 47, 45, and 35%. Overexpression of aakg-2 toegther with D. rerio ucp2 was non-additive with sDR [22737090]. | Nematode |
| abu-11 | Activated in Blocked Unfolded protein response 11 | Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. | Nematode |
| agmo-1 | AlkylGlycerol MonoOxygenase 1 | RNA interference of agmo-1 decreases median lifespan by 30% in wild type animals and 60% in daf-2 mutants [18006689]. | Nematode |
| ain-1 | ALG-1 INteracting protein 1 | RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| alg-1 | Argonaute (plant)-Like Gene | Adult-specific knockdown of the C. elegans argonaute-like gene 1 alg-1 results in shortened lifespan with a reduction in the mean and maximum lifespan by 9 - 16% and 14%, respectively [21810936]. | Nematode |
| alg-2 | Argonaute (plant)-Like Gene 2 | RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. | Nematode |
| aqp-1 | AQuaPorin or aquaglyceroporin related 1 | aqp-1 expression changes in response to glucose or glycerol. Similar to daf-16 and hsf-1 mutants, aqp-1 mutants were short-lived, and their short lifespan was not further decreased by glucose. Overexpression of aqp-1::GFP rescues short lifespan of aqp-1 deletion mutants and partially prevented glucose from shortening lifespan. Glucose or glycerol feeding downregulates aqp-1 in wild-type. In daf-16 and/or hsf-1 mutants aqp-1 is repressed and glucose feeding does not significantly affect its expression. aqp-1 mutation does not further decrease the short lifespan of daf-16 and/or hsf-1 mutants. aqp-1 transgene is expressed in pharynx and intestine (which behaves as entire endoderm of animal, including adipose tissues). Dietary glucose does not cause significant differences in levels of glucose or glycerol in wild-type vs. aqp-1 mutants [19883616]. | Nematode |
| arl-8 | ARF-Like 8 | RNA interference of arl-8 decreases median lifespan by 35% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| arx-4 | ARp2/3 compleX component 4 | RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| atp-3 | ATP synthase subunit | RNA interference against atp-3 results in lifespan extension [16103914]. atp-3 RNAi increases lifespan by 46% (mean by 33 and maximum by 70%). RNAi of atp-3 during larval stage is necessary and sufficient for lifespan prologation, while atp-3 RNAi only during the adulthood fails the extend lifespan. atp-3 RNAi results in reduced pharageal pumping, defection and motility as well as ATP levels and body size [12471266]. | Nematode |
| bar-1 | beta-catenin | BAR-1 may play a role in regulating daf-16 during dauer formation, particularly in conditions of oxidative stress as it directly interaction with DAF-16 and loss of bar-1 reduces activity of DAF-16 in dauer formation and lifespan. Deletion of bar-1 reduces mean (44%) and maximal (18%) lifespan, which is to a similar degree as seen to daf-16 mutants [15905404]. SMK-1 is important DAF-16 modulation of lifespan and specific stress response [5]. | Nematode |
| bec-1 | BEClin (human autophagy) homolog 1 | bec-1 is required for normal dauer morphogenesis and lifespan extension. Knockdown of bec-1 via RNA interference results in a shortened mean and maximum lifespan by 14 and 5% [12958363]. bec-1 RNAi does not significantly change the lifespan of wild-type, but completely suppresses the longevity phenotype of eat-2 mutation [17912023; 18282106] and prevents lifespan extension by daf-2(e1370) mutation [12958363]. bec-1 RNAi causes the formation of abnormal dauers in a daf-2(e1379) background [12958363]. | Nematode |
| blmp-1 | Blimp1 (B Lymphocyte-induced Maturation Protein-1) homolog 1 | RNA interference of blmp-1 decreases median lifespan by 17% in a daf-2 background and 20% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| BNA6 | Biosynthesis of Nicotinic Acid 6 | Deletion of BNA6 (alias QPT1) has no effect on replicative lifespan and is not required for lifespan extension by DR, but is lethal with mutation of NPT1 [11000115]. Deletion of BNA6 decreases chronological lifespan [17110466]. | Nematode |
| bra-1 | BMP receptor Associated protein family | bra-1(nk1) mutation reduces mean lifespan by 6-25% [17900898]. | Nematode |
| bus-8 | Bacterially Un-Swollen (M. nematophilum resistant) 8 | RNA interference of tag-249 decreases median lifespan by 58% in wild-type animals, 81% in a daf-2 background and 45% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C01F1.1 | — | RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C06A5.1 | — | RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C07A9.2 | — | RNA interference of C07A9.2 decreases median lifespan by 26% in wild type animals, 37% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C11H1.3 | — | RNA interference of C11H1.3 decreases median lifespan by 10% in wild type animals, 14% in a daf-2 background and 41% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| C14A4.9 | — | RNA interference of C14A4.9 decreases median lifespan by 14% in wild type animals and 41% in daf-2 mutants [18006689]. | Nematode |
| C26B9.3 | — | RNA interference ofC26B0.3 decreases median lifespan by 12% in wild type animals, 68% in a daf-2 background and 17% in daf-2/daf-16 double mutants [18006689]. | Nematode |
