| aat-8 | Amino Acid Transporter 8 | RNA interference of aat-8 increases mean lifespan by 30% [17608836]. | Nematode |
| abcx-1 | ABC transporter, eXtended 1 | RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. | Nematode |
| acl-11 | ACyLtransferase-like 11 | RNA interference of acl-11 leads to lifespan extension [12447374]. | Nematode |
| aco-2 | ACOnitase | RNA interference of aco-2 leads to lifespan extension [15998808]. | Nematode |
| acs-5 | fatty Acid CoA Synthetase family 5 | RNA interference of acs-5 increases mean lifespan by 52% [17608836]. | Nematode |
| age-1 | AGEing alteration 1 | Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740].
RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672].
age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. age-1 RNAi and mutation extend lifespan by 30% and 100%, respectively [8700226; 8608934]. | Nematode |
| age-2 | — | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Nematode |
| akt-1 | AKT kinase family 1 | RNA interference of akt-1 leads to lifespan extension [15998808]. | Nematode |
| amt-2 | AMmonium Transporter homolog 2 | RNA interference of amt-2 increases mean lifespan by 20% [17608836]. | Nematode |
| ant-1.1 | Adenine Nucleotide Translocator 1.1 | RNA interference of ant-1.1 increases mean lifespan by 40% [17608836]. | Nematode |
| aps-1 | AdaPtin, Small chain (clathrin associated complex) 1 | aps-1 RNAi in the adulthood extends mean lifespan by 8% without any apparent effect on maximum lifespan [23144747]. | Nematode |
| asb-1 | ATP Synthase B homolog | asb-1 RNAi in the adulthood extends the mean lifespan by 7% without changing the maximum lifespan [23144747]. | Nematode |
| asb-2 | ATP Synthase B homolog 2 | RNA interference of abs-2 leads to lifespan extension [16103914]. | Nematode |
| asg-1 | ATP Synthase G homolog 1 | RNA interference of asg-1 leads to lifespan extension [15998808]. | Nematode |
| asg-2 | ATP synthase subunit 2 | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Nematode |
| asm-3 | Acid SphingoMyelinase 3 | RNA interference of asm-3 increases mean lifespan by 50% [17608836]. | Nematode |
| atp-2 | ATP synthase F1 subunit gamma 2 | RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594]. | Nematode |
| atp-4 | ATP synthase subunit 4 | RNA interference of atp-4 results in lifespan extension [16103914]. | Nematode |
| atp-5 | ATP synthase subunit 5 | RNA interference of atp-5 results extended lifespan [16103914]. | Nematode |
| B0035.12 | — | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Nematode |
| B0491.5 | — | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Nematode |
| B0511.6 | — | RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. | Nematode |
| B0546.3 | — | RNA interference of B0546.3 increases mean lifespan by 27% [17608836]. | Nematode |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| C09B7.2 | transposase | RNA interference of C09B7.2 extends lifespan [15998808]. | Nematode |
