| C33A12.1 | — | RNA interference of C33A12.1 increase mean lifespan by 40% [17608836]. | Nematode |
| C33F10.12 | — | RNA interference of C33H5.18 extends lifespan [15998808]. | Nematode |
| C35A11.3 | — | RNA interference of C35A11.3 extends lifespan [15998808]. | Nematode |
| C36H8.1 | — | RNA interference of C36H8.1 extends lifespan [15998808]. | Nematode |
| C42C1.3 | — | RNA interferenceof C42C1.3 increases mean lifespan by 60% [17608836]. | Nematode |
| C46G7.2 | — | RNA interference of C46G7.2 increases mean lifespan by 44% [17608836]. | Nematode |
| C47D12.2 | TRRAP-like (transcription/transformation domain-associated protein) | C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. | Nematode |
| C47E12.2 | — | RNA interference of C47E12.2 increases mean lifespan by 36% [17608836]. | Nematode |
| C48E7.2 | — | RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. | Nematode |
| C56G2.1 | — | RNA interference of C56G2.1 in adulthood results in a 20% increase in mean lifespan [17411345]. | Nematode |
| cco-1 | Cytochrome C Oxidase | RNA interference of cco-1 results in a 45-61% increase in mean lifespan (in fer-15; fem-1 and N2 background, respectively) [16103914]. RNAi against cco-1 increases mean and maximum lifespan by 73% and 90%, respectively [12471266]. cco-1 RNAi extends mean and maximum lifespan by 41 and 50%. RNAi of cco-1 during the larval stages is necessary and sufficient for increased lifespan, while only during the adulthood it fails to to extend lifespan. cco-1 RNAi results in reduced pharyngeal pumping, defecation, motility, and body size as well as reduced ATP levels (by 60-80%) and oxygen consumption. daf-16 mutation fails to prevent lifespan extenison by RNAi of cco-1 and mutation of daf-2 further extends the lifespan of cco-1 RNAi animals [12447374]. RNAi of cco-1 only during the adulthood increases mean and 75th %ile lifespan by 22-32 and 16-33%, respectively [22560223]. | Nematode |
| cco-2 | Cytochrome C Oxidase 2 | RNA interference of cco-2 results in a 53-57% increase in mean lifespan [16103914]. | Nematode |
| CCR4 | Carbon Catabolite Repression 4 | Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. | Budding yeast |
| cct-4 | Chaperonin Containing TCP-1 4 | RNA interference of cct-4 in adulthood results in a 28% increase in mean lifespan [17411345]. | Nematode |
| cct-6 | Chaperonin Containing TCP-1 6 | RNA interference cct-6 in adulthood results in a 20% increase in mean lifespan [17411345]. | Nematode |
| cdc-25.1 | Cell Division Cycle related 25.1 | RNA interference of cdc-25.1 results in increased thermotolerance and extended lifespan [16741121]. cdc-25.1 RNAi extends mean and maximum lifespan by 10 and 13%, respectively [21129974].
Lifespan extension by cdc-25.1 RNAi is cancelled out by mir-71 mutation [21129974]. | Nematode |
| cdc-25.3 | Cell Division Cycle related 25.3 | RNA interference against cdc-25.3 extends lifespan [16741121]. cdc-25.3 RNAi in the adulthood extends the lifespan [New longevity regulators]. cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. | Nematode |
| CDC25 | Cell Division Cycle 25 | The CDC25-10 allele extends mean and maximum replicative lifespan by 34% and 18%, respectively, at 30 degree Celsius. cdc25-10 mutants have an extended replicative lifespan under AL. Growth on 0.5% glucose restriction does not further extend replicative lifespan of cdc25-10 mutants. CDC25 null mutant is not viable. CDC25 appears to act in the same genetic pathway as SIR2 and NPT1 and is suggested to be genetic model of DR [11000115]. | Budding yeast |
| CDC6 | Cell Division Cycle | The CDC6-1 conditional allele results in an approximately 20% increase in mean replicative life span. This allele is defective for replicative initiation form the rDNA ARS at 27 degree Celsius, resulting in a reduced rate of extrachromosomal rDNA circle accumulation [9428525]. The cdc6-1 allele results in genomic instability at the permissive temperature [8552037]. | Budding yeast |
| Cdkn1a | Cyclin-dependent kinase inhibitor 1A | Deletion of Cdkna1 (alias p21) prolongs the lifespan of telomerase-deficient mice with dysfunctional telomeres and improves the repopulation capacity and self-renewal of hematopoietic stem cells [17143283].
The p21(-/-) strains like the Cdkn1a(tmi/Tyj) exhibits enormous regenerative capacities as it closes ear holes similar to MRL mice [20231440; 21722344]. | House mouse |
| Cebpa | CCAAT/enhancer binding protein (C/EBP), alpha | Replacing the Cebpa gene by Cebpb increases mean lifespan by about 20% [15289464]. C/ebpalpha(beta/beta) animals consume more food but weight less than controls [10982846], and have a slightly elevated body temperature (0.3-0.5 degree Celsius) [15289464]. | House mouse |
| ced-3 | CEll Death abnormality | RNA interference of ced-3 in adulthood results in a 19% increase in mean lifespan [17411345]. The ced-3(n1286) allele has no effect on lifespan, although the transgenic animals are defective in apoptosis [12136014]. | Nematode |
| ceh-18 | C. Elegans Homeobox 18 | RNA interference of ceh-18 extends lifespan [15998808]. | Nematode |
| cep-1 | C. Elegans P-53-like protein 1 | RNA interference of cep-1 increases mean lifespan up to 18% and mutants live up to 33% longer. Both are dependent upon functional daf-16 [17895432]. | Nematode |
| CG17856 | — | RNAi of CG17856 results in an increase in mean lifespan of 13-18% in females. In the case of males and post-developmental experiments the results are variable [19747824]. | Fruit fly |
