| ATG11 | AuTophaGy related 11 | ATG11 deletion extends replicative lifespan under AL and abrogates DR-lifespan extension [18690010]. | Budding yeast |
| ATH1 | Acid TreHalase | Deletion of ATH1 extend the mean chronological lifespan by 17% (at 30 degree Celsus in BY4742) [22783207].
ATH1 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| atp-2 | ATP synthase F1 subunit gamma 2 | RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594]. | Nematode |
| atp-4 | ATP synthase subunit 4 | RNA interference of atp-4 results in lifespan extension [16103914]. | Nematode |
| atp-5 | ATP synthase subunit 5 | RNA interference of atp-5 results extended lifespan [16103914]. | Nematode |
| ATP1 | ATP synthase 1 | Deletion of ATP1 increases chronological lifespan by up to 50% [17492370], but decreases replicative lifespan by 70% in the alpha strain [18340043]. | Budding yeast |
| AVO2 | Adheres VOraciously (to TOR2) | Deletion of AVO2 extends chronological lifespan [21641548]. | Budding yeast |
| B0035.12 | — | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Nematode |
| B0491.5 | — | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Nematode |
| B0511.6 | — | RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. | Nematode |
| B0546.3 | — | RNA interference of B0546.3 increases mean lifespan by 27% [17608836]. | Nematode |
| BAS1 | BASal 1 | Deletion of BAS1 increases replicative lifespan by 30% in the alpha strain [16293764; 19030232]. | Budding yeast |
| bchs | blue cheese | Loss of function mutation in bchs results in a 40-45% decrease in mean lifespan and is associated with age-related neurodegenerative phenotype with reduced CNS size and altered morphology as well as accumulation of insoluble ubiquinated proteins and amyloid precursor-like proteins along with an increase in neuronal apoptosis. No pronounced developmental defects were observed and young adults have normal behaviours, indicating that the bchs gene is essential for normal adult survival and longevity [12598614].
bchs mutation reduces mean lifespan by 28 - 54% and maximum lifespan by 24 - 46% [17435236].
Alfy (autophagy-linked FYVE protein) is the conserved human bchs homolog [15292400]. | Fruit fly |
| Bmcp | Mitochondrial uncoupler | Bmcp knockout flies live longer on low-calorie diets, have a decreased fertility, and gain less weight on high-calorie diets. Bmcp (ucp5) knockout mutants live longer than wild-type on low-calorie diets, but no longer on starvation or high-calorie diets. Ectopic neuronal expression of Bmcp transgene rescues starvation sensitive phenotype of Bmcp knockout mutants [16387864]. | Fruit fly |
| BMH1 | Brain Modulosignalin Homologue 1 | Deleting BMH1 extends chronological lifespan by 25% and is associated with activated stress response, decreased ROS levels and increased heat-shock-element-driven transcription activity. BMH1 deletion was non-additive with the genetic DR mimetic cdc25 and tor1. Water starvation (a form of extreme DR) extends chronological lifespan of BMH1 mutant even more as it does in wild-type. BMH1 genetically interacts with DR as well as TOR- and PKA-signaling pathways to regulate lifespan. Phosphorylation of Ser238 on Bmh1 increases during chronological aging, which is delayed by DR or reduced TOR activity [19805817].
| Budding yeast |
| BRE5 | BREfeldin A sensitivity 5 | Deletion of BRE5 increases mean replicative lifespan by 30% [16293764] and mean chronological lifespan in diploid cells [21447998] | Budding yeast |
| bub-3 | yeast BUB homolog | RNAi against bub-3 increases mean and maximum lifespan by 6-7% and 7%, respectively [18059442]. | Nematode |
| bwa | brain washing | bwa (alias Dacer) inactivation increases Drosophila pre-adult development time and anti-oxidative stress capacity. Mean lifespan is increased by 16% in females, by 21% in males and by 19% in total. Maximum lifespan of females, males is also extended by 20 and 12%, respectively [20112046]. | Fruit fly |
| C09B7.2 | transposase | RNA interference of C09B7.2 extends lifespan [15998808]. | Nematode |
| C18E9.10 | — | RNA interference of C18E9.10 results in lifespan extension [15998808]. | Nematode |
| C18E9.4 | — | RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. | Nematode |
| C26B2.2 | — | C26B2.2 knockout mutations extend lifespan [15253933]. | Nematode |
| C27B7.7 | — | RNA interference of C27B7.7 extends lifespan [15998808]. | Nematode |
| C32H11.1 | — | RNA interference of C32H11.1 extends lifespan [12845331]. | Nematode |
| C32H11.5 | — | RNA interference of C32H11.5 extends lifespan [15998808]. | Nematode |
