| ATF4 | — | ATF4 was not found to be associated with longevity [23770741]. | Human |
| ATXN1 | ataxin 1 | ATXN1 was not found to be associated with longevity [21612516]. | Human |
| B9D2 | B9 protein domain 2 | B9D2 was not found to be associated with longevity [15569360]. | Human |
| BIN1 | bridging integrator 1 | BIN1 was not found to be associated with longevity [22445811]. | Human |
| C3 | complement component 3 | Genetic variations in C3 are not associated with longevity in Italian [10219002]. | Human |
| C4A | complement component 4A (Rodgers blood group) | Genetic variations in C4A are not associated with longevity in Italian [10219002]. | Human |
| C4B | complement component 4B (Chido blood group) | Genetic variations in C4B are not associated with longevity in Italian [10219002]. | Human |
| CAD | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | CAD was not found to be associated with longevity [15621215]. | Human |
| CAT | catalase | Overexpression of human catalase targeted to mitochondria (MCAT) extends mean and maximum lifespan by about 20% in mice. Inactivation of aconitase in heat mitochondria and mitochondrial damage is also reduced in long-lived CAT mutant mice [15879174].
The MCAT strain has a reduced severity of age-dependent arteriosclerosis and increased genomic stability, as indicated by an decrease in oxidative stress and mitochondrial deletions in heart and muscle tissues. Median and maximum lifespan in increased about 17 - 21% [16144468].CAT was not found to be associated with longevity [15472150]. | Human |
| CBL | — | CBL was not found to be associated with longevity [23770741]. | Human |
| CCL5 | chemokine (C-C motif) ligand 5 | CCL5 was not found to be associated with longevity [22265023]. | Human |
| CCR5 | chemokine (C-C motif) receptor 5 | CCR5 was not found to be associated with longevity [22265023]. | Human |
| CCR5 | chemokine (C-C motif) receptor 5 | CCR5 was not found to be associated with longevity [22265023]. | Human |
| CD2AP | CD2-associated protein | CD2AP was not found to be associated with longevity [22445811]. | Human |
| CD33 | CD33 molecule | CD33 was not found to be associated with longevity [22445811]. | Human |
| CDH23 | cadherin-related 23 | CDH23 was not found to be associated with longevity [21612516]. | Human |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDKN1A was found to be associated with longevity [20126416]. CDKN1A was found to be associated with longevity [20126416]. CDKN1A was not found to be associated with longevity [20126416]. | Human |
| CDKN2B-AS1 | CDKN2B antisense RNA 1 | CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. | Human |
| CETP | cholesteryl ester transfer protein, plasma | Homozygousity for the I405V variant of CETP is associated with exceptional longevity and larger HDL and LDL particle sizes as well as lower prevalence of hypertension, cardivascular disease, and metabolic disease among Askenazi Jews [14559957]. CETP I405V homozygousity is associated with exceptional longevity and preservation of cognitive function in Askenazi Jews [17190939].
V/V homozygotes tend to have a 9-23% CETP deficiency [9610775; 15243211]. A decrease in CETP function increases HDL (high density lipoproteins) levels in the body, and decreases LDL (low-density lipoprotein). The result of this s that HDL-c levels are approximately equal in individuals with the I/I or I/V genotypes, while there are ten percent higher in V/V individuals [9610775].
Therefore the V/V SNP acts kind like an endogenous *CEPT inhibitor*, which might be the responsible for the increase in longevity but may also have side effects.CETP was found to be associated with longevity [22336474].CETP was found to be associated with longevity [15621216].CETP was found to be associated with longevity [15888337]. CETP was found to be associated with longevity [22234866]. CETP was found to be associated with longevity [22336474]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [15621216]. CETP was found to be associated with longevity [15888337]. CETP was not found to be associated with longevity [23389097]. CETP was found to be associated with longevity [14559957]. CETP was found to be associated with longevity [16602826]. CETP was found to be associated with longevity [23162014]. CETP was not found to be associated with longevity [14559957]. CETP was found to be associated with longevity [18034366]. CETP was not found to be associated with longevity [24468472]. | Human |
| CFB | complement factor B | Genetic variations in CFB are not associated with longevity in Italian [10219002]. | Human |
| CFLAR | CASP8 and FADD-like apoptosis regulator | CFLAR was not found to be associated with longevity [21612516]. | Human |
| CLU | clusterin | CLU was found to be associated with longevity [16804001]. CLU was not found to be associated with longevity [22445811]. | Human |
| COQ7 | coenzyme Q7 homolog, ubiquinone (yeast) | COQ7 was not found to be associated with longevity [18765803]. | Human |
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) | CR1 was not found to be associated with longevity [22445811]. | Human |
| CRP | C-reactive protein, pentraxin-related | CRP was not found to be associated with longevity [17888441]. | Human |
