| — | (-)-epidcatechin | Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. | Nematode |
| aak-1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | aak-1 does not appear to be required for the control of lifespan [15574588]. | Nematode |
| acdh-1 | Acyl CoA DeHydrogenase 1 | RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| acdh-12 | Acyl CoA DeHydrogenase 12 | RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. | Nematode |
| asp-3 | ASpartyl Protease 3 | RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi. ASP-3 is upregulated in eat-2 mutants [22810224]. | Nematode |
| BNA6 | Biosynthesis of Nicotinic Acid 6 | Deletion of BNA6 (alias QPT1) has no effect on replicative lifespan and is not required for lifespan extension by DR, but is lethal with mutation of NPT1 [11000115]. Deletion of BNA6 decreases chronological lifespan [17110466]. | Nematode |
| ced-3 | CEll Death abnormality | RNA interference of ced-3 in adulthood results in a 19% increase in mean lifespan [17411345]. The ced-3(n1286) allele has no effect on lifespan, although the transgenic animals are defective in apoptosis [12136014]. | Nematode |
| ctl-1 | CaTaLase 1 | ctl-1 loss of function shortens lifespan to 77% of wild-type animals. ctl-1 mutants accumulate fluorescent material faster than wild-type, indicating accelerated aging [12610632]. ctl-1 mutation prevents lifespan extension by daf-2 or clk-1. Mutation of ctl-1 reudces catalase activty by 50% [10335847].
All these results have been retracted. | Nematode |
| cul-1 | CULlin 1 | RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. | Nematode |
| daf-1 | abnormal DAuer Formation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Nematode |
| daz-1 | human DAZ (Deleted in Azoospermia) homolog | Mutation of daz-1 has no effect on lifespan [11799246]. daz-1 mutants are sterile and have a gonad that contains small nuclei and no oocytes [10662646]. Although sperm production is normal, oocytes precursors arrest at meiotic prophase and undergo apoptosis | Nematode |
| dod-19 | Downstream Of DAF-16 (regulated by DAF-16) | RNA interference of dod-19 extends lifespan by 28%. dod-19 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| eat-10 | EATing: abnormal pharyngeal pumping 10 | The eat-10(ad606) allele exhibits no significant extension of lifespan [9789046], but displays defects in pharyngeal feeding behaviour [8462849]. | Nematode |
| eat-5 | EATing: abnormal pharyngeal pumping 5 | The eat-5(ad464) allele has no significant effect on lifespan [9789046], although it displays defects in pharyngeal feeding behaviour [8462849]. | Nematode |
| fbxa-121 | F-box A protein | RNA interference of fbxa-121 in adulthood shortens the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts [17392428]. | Nematode |
| fem-3 | FEMinization of XX and XO animals | fem-3(e1996) mutants do not produce sperm or self-progeny, therefore develop as females, but have a normal lifespan (See also ref 10) [8247153]. | Nematode |
| fog-1 | Feminization Of Germline | The fog-1(q180) allele has no effect on lifespan [11799246]. fog-1 mutants are sterile and make oocytes but not sperm [2341035]. | Nematode |
| fog-2 | Feminization Of Germline 2 | fog-2(q71) allele has no effect on lifespan [10747056]. fog-2 mutant display hermaphrodite specific germ line feminization [11076749]. | Nematode |
| fog-3 | Feminization Of Germline 3 | The fog-3(q470) allele has no effect on lifespan [11799246]. In fog-3 mutant animals cells that would normally become sperm differentiate into oocytes [7713418]. | Nematode |
| ins-22 | INSulin related 22 | RNAi of ins-22 has no effect on lifespan. ins-22 is differentially transcribed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| lars-2 | Leucyl Amino-acyl tRNA Synthetase | A mutation that impairs mitochondrial function was associated with a longer lifespan. Mutation of lrs-2/lars-2(mg312) extends lifespan and is associated with impaired mitochondrial function. The recessive allele mg312 of lars-2 extends lifespan by 200% at 20 degree Celsius and 30% at 25 degree Celsius. Lifespan extension by mg312 was not dependent on daf-16(mgDf47). Homozygous lars-2(mg312) worms had multiple pleotropies like lower rates of growth, pumping and defecation as well as remain the size of early L4 worms and are sterile, with an arrested gonad that exhibited no germ-cell differentiation lars-2 is ubiquitously express, with prominent expression in body-wall muscle and neurons, with a mitochondrial subcellular localisation. Mitochondria of lars-2 are noticeably disorganized, swollen and sometimes fused. lars-2 animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
| mec-1 | MEChanosensory abnormality 1 | Loss of function mutations in mec-1 do not effect lifespan [2428682]. mec-1 mutants are touch insenstive, lethargic, and have displacement of some microtubule cells and amphidial neurons as well as defective fasciculation [2428682]. | Nematode |
| NAC | N-acetyl cysteine | Treatment with 10 mM of NAC has no effect on the lifespan of wild-type, but fully abolishes the increased longevity of nuo-6 and severly limits that of isp-1. At high concentration (> 10-15 nM) NAC can be become deleteroius even on the wild-type [21151885]. | Nematode |
| pod-2 | Polarity and Osmotic sensitivity Defect 2 | RNA interference of pod-2 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. POD-2 is downregulated in eat-2 [22810224]. | Nematode |
| pyc-1 | PYruvate Carboxylase 1 | RNA interference of pyc-1 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. PYC-1 is downregulated in eat-2 mutants [22810224]. | Nematode |
