| CCL5 | chemokine (C-C motif) ligand 5 | CCL5 was not found to be associated with longevity [22265023]. | Human |
| CCR5 | chemokine (C-C motif) receptor 5 | CCR5 was not found to be associated with longevity [22265023]. | Human |
| CCR5 | chemokine (C-C motif) receptor 5 | CCR5 was not found to be associated with longevity [22265023]. | Human |
| CD2AP | CD2-associated protein | CD2AP was not found to be associated with longevity [22445811]. | Human |
| CD33 | CD33 molecule | CD33 was not found to be associated with longevity [22445811]. | Human |
| CDH23 | cadherin-related 23 | CDH23 was not found to be associated with longevity [21612516]. | Human |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDKN1A was found to be associated with longevity [20126416]. CDKN1A was found to be associated with longevity [20126416]. CDKN1A was not found to be associated with longevity [20126416]. | Human |
| CDKN2B-AS1 | CDKN2B antisense RNA 1 | CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. | Human |
| ced-3 | CEll Death abnormality | RNA interference of ced-3 in adulthood results in a 19% increase in mean lifespan [17411345]. The ced-3(n1286) allele has no effect on lifespan, although the transgenic animals are defective in apoptosis [12136014]. | Nematode |
| CETP | cholesteryl ester transfer protein, plasma | Homozygousity for the I405V variant of CETP is associated with exceptional longevity and larger HDL and LDL particle sizes as well as lower prevalence of hypertension, cardivascular disease, and metabolic disease among Askenazi Jews [14559957]. CETP I405V homozygousity is associated with exceptional longevity and preservation of cognitive function in Askenazi Jews [17190939].
V/V homozygotes tend to have a 9-23% CETP deficiency [9610775; 15243211]. A decrease in CETP function increases HDL (high density lipoproteins) levels in the body, and decreases LDL (low-density lipoprotein). The result of this s that HDL-c levels are approximately equal in individuals with the I/I or I/V genotypes, while there are ten percent higher in V/V individuals [9610775].
Therefore the V/V SNP acts kind like an endogenous *CEPT inhibitor*, which might be the responsible for the increase in longevity but may also have side effects.CETP was found to be associated with longevity [22336474].CETP was found to be associated with longevity [15621216].CETP was found to be associated with longevity [15888337]. CETP was found to be associated with longevity [22234866]. CETP was found to be associated with longevity [22336474]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [15621216]. CETP was found to be associated with longevity [15888337]. CETP was not found to be associated with longevity [23389097]. CETP was found to be associated with longevity [14559957]. CETP was found to be associated with longevity [16602826]. CETP was found to be associated with longevity [23162014]. CETP was not found to be associated with longevity [14559957]. CETP was found to be associated with longevity [18034366]. CETP was not found to be associated with longevity [24468472]. | Human |
| CFB | complement factor B | Genetic variations in CFB are not associated with longevity in Italian [10219002]. | Human |
| CFLAR | CASP8 and FADD-like apoptosis regulator | CFLAR was not found to be associated with longevity [21612516]. | Human |
| CIT2 | CITrate synthase 2 | Deletion or overexpression of CIT2 has no effect on replicative lifespan. CIT2 is not required for the strain specific lifespan extension in petite cells [10224252], although it is transcribed up to 30-fold higher in petite cells relative to grande cells [1986232]. | Budding yeast |
| CLU | clusterin | CLU was found to be associated with longevity [16804001]. CLU was not found to be associated with longevity [22445811]. | Human |
| COQ7 | coenzyme Q7 homolog, ubiquinone (yeast) | COQ7 was not found to be associated with longevity [18765803]. | Human |
| CPR7 | Cyclosporin-sensitive Proline Rotamase 7 | Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] | Budding yeast |
| CR1 | complement component (3b/4b) receptor 1 (Knops blood group) | CR1 was not found to be associated with longevity [22445811]. | Human |
| CRP | C-reactive protein, pentraxin-related | CRP was not found to be associated with longevity [17888441]. | Human |
| ctl-1 | CaTaLase 1 | ctl-1 loss of function shortens lifespan to 77% of wild-type animals. ctl-1 mutants accumulate fluorescent material faster than wild-type, indicating accelerated aging [12610632]. ctl-1 mutation prevents lifespan extension by daf-2 or clk-1. Mutation of ctl-1 reudces catalase activty by 50% [10335847].
All these results have been retracted. | Nematode |
| cul-1 | CULlin 1 | RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. | Nematode |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | CYP1A1 was not found to be associated with longevity [15177664]. CYP1A1 was not found to be associated with longevity [15195682]. | Human |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | CYP1B1 was not found to be associated with longevity [15177664]. | Human |
| CYP2C19 | cytochrome P450, family 2, subfamily C, polypeptide 19 | CYP2C19 was not found to be associated with longevity [9754988]. | Human |
| CYT1 | cytochrome c1 | Deletion of CYT1 increases replicative lifespan by 15% in the alpha strain and decreases replicative lifespan by 20% in a strain. Deletion of CYT1 decreases replicative lifespan and cancels out replicative lifespan extension by HAP4 overexpression. Initially, it was shown that deletion of CYT1 also prevents lifespan extension by 0.5% glucose restriction [12124627], but later it was shown that either 0.5 or 0.05 % glucose restriction increases replicative lifespan of cyt1Delta cells [16311627]. | Budding yeast |
| daf-1 | abnormal DAuer Formation | daf-1(mk40) mutation increases mean lifespan by 18-46% and maximum lifespan by 29% [17900898]. The daf-1(m40) allele has no effect on lifespan and fails to prevent lifespan extension by sir-2.1 overexpression, but it results in a temperautre-sensitive, dauer-constitutive phenotype in larvae [11242085]. | Nematode |
