| FOXO3A | forkhead box O3 | FOXO3A was found to be associated with longevity [19415983]. FOXO3A was found to be associated with longevity [20849522]. FOXO3A was found to be associated with longevity [19489743]. FOXO3A was found to be associated with longevity [21418511]. FOXO3A was not found to be associated with longevity [19489743]. FOXO3A was found to be associated with longevity [19196970]. FOXO3A was found to be associated with longevity [25038186]. FOXO3A was not found to be associated with longevity [25038186]. | Human |
| GHR | growth hormone receptor | Individuals with low GH/IGF-I signaling due to a defect in the growth hormone receptor (GHR) are protected against cancer. Among the human individuals with a defect in GHR no cancer deaths were observed. GHR deficiency does not appear to extend lifespan because it is associated with increased risk of heart disease [21325617]. Variants in GHR were found to be associated with longevity [19489743]. | Human |
| GHRHR | growth hormone releasing hormone receptor | GHRHR was found to be associated with longevity [22406557]. GHRHR was not found to be associated with longevity [19489743]. | Human |
| GSTM1 | glutathione S-transferase mu 1 | GSTM1 was found to be associated with longevity [9654200]. GSTM1 was found to be associated with longevity [9654200]. GSTM1 was found to be associated with longevity [16574194]. GSTM1 was not found to be associated with longevity [15195682]. | Human |
| GSTT1 | glutathione S-transferase theta 1 | Deletion in the GSTT1 was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age. A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects [11162685].GSTT1 was found to be associated with longevity [11162685]. GSTT1 was found to be associated with longevity [16574194]. GSTT1 was not found to be associated with longevity [11162685]. GSTT1 was not found to be associated with longevity [15195682]. | Human |
| HFE | hemochromatosis | C282Y, H63D and S65C polymorphisms in the HFE gene were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women). A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people [11857056].HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [12714263]. HFE was not found to be associated with longevity [11857056]. HFE was not found to be associated with longevity [12714263]. | Human |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | olymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQA10101=0104 and DQA105 alleles were significantly increased in the centenarians [9389323].HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was not found to be associated with longevity [17714903]. | Human |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | Polymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQB105 and DQB103 alleles were significantly increased in the centenarians [9389323].HLA-DQB1 was found to be associated with longevity [9389323]. HLA-DQB1 was not found to be associated with longevity [17714903]. | Human |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | Polymorphisms in the HLA-DRB1 gene in Okinawan centenarians were analyzed. DRB1*1401 allele was significantly increased in the centenarians while DRB1*0101 and DRB1*1201 alleles were slightly decreased [9389323].HLA-DRB1 was found to be associated with longevity [9425225].HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9389323]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [20426625]. HLA-DRB1 was not found to be associated with longevity [16269080]. | Human |
| HRAS1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | HRAS1 was found to be associated with longevity [19367319]. HRAS1 was not found to be associated with longevity [19367319]. | Human |
| IFNG | interferon, gamma | The distribution of 874T/A polymorphism in the IFNG gene was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men). The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls [11772518].IFNG was found to be associated with longevity [21299522]. IFNG was not found to be associated with longevity [11772518]. IFNG was found to be associated with longevity [11772518]. | Human |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | Males exhibit an age-related increase in the A-allele of rs2229765 and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age. In males +over 85 years, A/A homozygous individuals have the lowest plasma IGF-1 level. However, ther was no clear correlation between rs2229765 genotype and IGF-1 in females [19460140].IGF1 was found to be associated with longevity [20199671]. IGF1 was found to be associated with longevity [18761080]. IGF1 was found to be associated with longevity [18761080]. IGF1 was found to be associated with longevity [18761080]. IGF1 was not found to be associated with longevity [19489743]. | Human |
| IGF2 | insulin-like growth factor 2 (somatomedin A) | A/G ApaI site SNP in the IGF2 gene was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years). An increase in the A allele was observed in older Ashkenazi females and a highly significant increase was observed in the AA genotype in these subjects [15621215].IGF2 was found to be associated with longevity [19367319]. IGF2 was not found to be associated with longevity [19367319]. IGF2 was found to be associated with longevity [17989723]. IGF2 was found to be associated with longevity [15621215]. | Human |
| IGSF4 | cell adhesion molecule 1 | IGSF4 was found to be associated with longevity [22279548]. IGSF4 was not found to be associated with longevity [21612516]. | Human |
| IL-6 | interleukin 6 (interferon, beta 2) | IL-6 was found to be associated with longevity [15664628]. IL-6 was found to be associated with longevity [11500818]. IL-6 was not found to be associated with longevity [15236771]. IL-6 was not found to be associated with longevity [11772517]. | Human |
| IL10 | interleukin 10 | The -1082G/A, -819C/T and -592C/A proximal promoter SNPs of the IL10 gene were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old). The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs [11857058].IL10 was found to be associated with longevity [20518833]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [11640949]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [11857058]. IL10 was found to be associated with longevity [15466015]. IL10 was not found to be associated with longevity [11640949]. | Human |
| IL1A | interleukin 1, alpha | IL1A was found to be associated with longevity [12714264]. IL1A was found to be associated with longevity [11640949]. IL1A was not found to be associated with longevity [12714264]. IL1A was not found to be associated with longevity [11640949]. | Human |
| IL1B | interleukin 1, beta | IL1B was found to be associated with longevity [12714264]. IL1B was found to be associated with longevity [11640949]. IL1B was found to be associated with longevity [11640949]. IL1B was not found to be associated with longevity [12714264]. IL1B was not found to be associated with longevity [11640949]. | Human |
| IL1RN | interleukin 1 receptor antagonist | IL1RN was found to be associated with longevity [12714264]. IL1RN was found to be associated with longevity [11640949]. IL1RN was not found to be associated with longevity [12714264]. IL1RN was not found to be associated with longevity [11640949]. | Human |
| IL2 | interleukin 2 | IL2 was found to be associated with longevity [21299522]. IL2 was not found to be associated with longevity [16518704]. | Human |
| INS | insulin | Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. INS was found to be associated with longevity [22406557; 19367319; 17989723; 19489743]. | Human |
| INSR | insulin receptor | 5 intronic and 1 exonic polymorphisms in the INSR gene were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33). One haplotype, which was comprised of 2 intronic SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls [15582274].INSR was found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [19489743]. | Human |
| IRS2 | insulin receptor substrate 2 | IRS2 was found to be associated with longevity [19887537]. IRS2 was not found to be associated with longevity [19489743]. | Human |
| KIR2DS4 | killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 | KIR2DS4 was found to be associated with longevity [15130674]. KIR2DS4 was found to be associated with longevity [15130674]. KIR2DS4 was not found to be associated with longevity [15130674]. | Human |
| KL | klotho | The KL-VS allele of the klotho gene is more common in infants than in elderly individuals. Individuals homozygous for KL-VS have a 2.6-fold greater chance of dying by age 65 than individuals that are homozyogous that are homozyogous for the wild-type klotho allele [11792841]. KL was found to be associated with longevity [17903295; 22406557; 15677572]. KL was not found to be associated with longevity [18034366]. KL was found to be associated with longevity [24164579]. | Human |
