Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    (-)-epidcatechin Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. Nematode
    D-glucosamine In budding yeast addition of 0.5 mg/ml D-glucosamine to the growth media suppresses the short replicative lifespan and temperature sensitive growth of mpt5 mutant, but fails to extend the lifespan of wild-type cells [11805047].
    Diabenol In female NMRI and transgenic HER-2/neu mice supplementation of diabenol with drinking water 5 times a week since the age of 2 months, increases survival and inhibits spontaneous carcinogenesis. In NMRI diabenol does not influence body weight gain dynamics, food and water consumption, but slowed down age-related disturbances in estrous function and increases the lifespan of all and 10% most long-living ones. Diabenol treatment in NMRI mice also inhibits spontaneous tumor incidence (mammary and lymphomas mainly) and increases mammary tumor latency. Diabenol treatment slows down age-related changes in estrous function in HER-2/neu mice, but fails to influence survival and slightly inhibited the incidence and decrease the size of mammary adenocarcinoma metastasis into the lung [15754958]. House mouse
    (R)-N-(2-heptyl)-N-methylpropargylamine Addition of 0.66 ng/fly/day (R)-N-(2-heptyl)-N-methylpropargylamine to a sucrose-based diet resulted in no significant effect on lifespan, but lifespan reduction due to galactose feeding is partially suppressed by supplementation with (R)-deprnyl or (R)-N-(2-heptyl)-N-methylpropargylamine [9972869]. Fruit fly
    GSTM1 glutathione S-transferase mu 1 GSTM1 was not found to be associated with longevity [11162685]. Human
    INS insulin INS was not found to be associated with longevity [19367319]. Human
    aak-1 5'-AMP-activated protein kinase catalytic subunit alpha-1 aak-1 does not appear to be required for the control of lifespan [15574588]. Nematode
    ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 The R219K SNP was examined in 256 centenarians and 190 healthy younger controls. The allelic frequency were not different between the two groups [12601526]. Human
    ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 ABCA7 was not found to be associated with longevity [22445811]. Human
    ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 ABCC8 was not found to be associated with longevity [21612516]. Human
    Acacb acetyl-Coenzyme A carboxylase beta Acacb-null animals (alias Acc2-/-) exhibit upon regular diet an increase triglyceride breakdown, leaner phenotype, increased insulin sensitivity and no effect on lifespan [17923673]. House mouse
    acdh-1 Acyl CoA DeHydrogenase 1 RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. Nematode
    acdh-12 Acyl CoA DeHydrogenase 12 RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. Nematode
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 ACE was not found to be associated with longevity [12634288]. Human
    ACE angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829]. I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559]. I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238]. I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214]. Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. Human
    ACTN3 actinin, alpha 3 ACTN3 was not found to be associated with longevity [21407828]. Human
    ADARB2 adenosine deaminase, RNA-specific, B2 ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. Human
    ADCY5 adenylate cyclase 5 ADCY5 was not found to be associated with longevity [23020224]. Human
    ADIPOQ10 adiponectin, C1Q and collagen domain containing ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. Human
    ADIPQO adiponectin, C1Q and collagen domain containing ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. Human
    ADRB1 adrenergic, beta-1-, receptor ADRB1 was not found to be associated with longevity [23020224]. Human
    ADRB2 adrenergic, beta-2-, receptor, surface ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. Human
    AFX forkhead box O4 AFX was not found to be associated with longevity [19489743]. Human
    AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) M/T235 SNP in the AGT gene was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) and a significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele [11602206].AGT was found to be associated with longevity [15621215]. AGT was found to be associated with longevity [11602206]. AGT was not found to be associated with longevity [15621215]. Human
    AGTR1 angiotensin II receptor, type 1 AGTR1 was found to be associated with longevity [22569962]. AGTR1 was not found to be associated with longevity [22569962]. Human
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    • 25 of 288 factors
    Factors are an extension of GenAge and GenDR.

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