Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Nematode « 
  • Classifications: + -
    Positive Gerontogene «  Aging‑Suppressor (7)   Negative Aging‑Suppressor (5)   Positive Aging‑Suppressor (2)   Gerontogene (265)   Negative Gerontogene (3)   DR‑Differential (2)   DR‑Induced (2)   DR‑Suppressed (2)   DR‑Essential (22)   DR‑Essential Paralog (1)   No Age Effect (4)  
  • Types: + -
    Gene (6)   Protein coding (5)   miRNA (1)  
    • symbol name observation species
    C18E9.10 — RNA interference of C18E9.10 results in lifespan extension [15998808]. Nematode
    C18E9.4 — RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. Nematode
    C26B2.2 — C26B2.2 knockout mutations extend lifespan [15253933]. Nematode
    C27B7.7 — RNA interference of C27B7.7 extends lifespan [15998808]. Nematode
    C32H11.1 — RNA interference of C32H11.1 extends lifespan [12845331]. Nematode
    C32H11.5 — RNA interference of C32H11.5 extends lifespan [15998808]. Nematode
    C33A12.1 — RNA interference of C33A12.1 increase mean lifespan by 40% [17608836]. Nematode
    C33F10.12 — RNA interference of C33H5.18 extends lifespan [15998808]. Nematode
    C35A11.3 — RNA interference of C35A11.3 extends lifespan [15998808]. Nematode
    C36H8.1 — RNA interference of C36H8.1 extends lifespan [15998808]. Nematode
    C42C1.3 — RNA interferenceof C42C1.3 increases mean lifespan by 60% [17608836]. Nematode
    C46G7.2 — RNA interference of C46G7.2 increases mean lifespan by 44% [17608836]. Nematode
    C47D12.2 TRRAP-like (transcription/transformation domain-associated protein) C47D12.2 RNAi in the adulthood extends mean and maximum lifespan by 6 and 9% [23144747]. Nematode
    C47E12.2 — RNA interference of C47E12.2 increases mean lifespan by 36% [17608836]. Nematode
    C48E7.2 — RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. Nematode
    C56G2.1 — RNA interference of C56G2.1 in adulthood results in a 20% increase in mean lifespan [17411345]. Nematode
    cco-1 Cytochrome C Oxidase RNA interference of cco-1 results in a 45-61% increase in mean lifespan (in fer-15; fem-1 and N2 background, respectively) [16103914]. RNAi against cco-1 increases mean and maximum lifespan by 73% and 90%, respectively [12471266]. cco-1 RNAi extends mean and maximum lifespan by 41 and 50%. RNAi of cco-1 during the larval stages is necessary and sufficient for increased lifespan, while only during the adulthood it fails to to extend lifespan. cco-1 RNAi results in reduced pharyngeal pumping, defecation, motility, and body size as well as reduced ATP levels (by 60-80%) and oxygen consumption. daf-16 mutation fails to prevent lifespan extenison by RNAi of cco-1 and mutation of daf-2 further extends the lifespan of cco-1 RNAi animals [12447374]. RNAi of cco-1 only during the adulthood increases mean and 75th %ile lifespan by 22-32 and 16-33%, respectively [22560223]. Nematode
    cco-2 Cytochrome C Oxidase 2 RNA interference of cco-2 results in a 53-57% increase in mean lifespan [16103914]. Nematode
    cct-4 Chaperonin Containing TCP-1 4 RNA interference of cct-4 in adulthood results in a 28% increase in mean lifespan [17411345]. Nematode
    cct-6 Chaperonin Containing TCP-1 6 RNA interference cct-6 in adulthood results in a 20% increase in mean lifespan [17411345]. Nematode
    cdc-25.1 Cell Division Cycle related 25.1 RNA interference of cdc-25.1 results in increased thermotolerance and extended lifespan [16741121]. cdc-25.1 RNAi extends mean and maximum lifespan by 10 and 13%, respectively [21129974]. Lifespan extension by cdc-25.1 RNAi is cancelled out by mir-71 mutation [21129974]. Nematode
    cdc-25.3 Cell Division Cycle related 25.3 RNA interference against cdc-25.3 extends lifespan [16741121]. cdc-25.3 RNAi in the adulthood extends the lifespan [New longevity regulators]. cdc-25.3 knockout mutants also display increased thermotolerance and a 40% lifespan extension [16741121]. Nematode
    ced-3 CEll Death abnormality RNA interference of ced-3 in adulthood results in a 19% increase in mean lifespan [17411345]. The ced-3(n1286) allele has no effect on lifespan, although the transgenic animals are defective in apoptosis [12136014]. Nematode
    ceh-18 C. Elegans Homeobox 18 RNA interference of ceh-18 extends lifespan [15998808]. Nematode
    cep-1 C. Elegans P-53-like protein 1 RNA interference of cep-1 increases mean lifespan up to 18% and mutants live up to 33% longer. Both are dependent upon functional daf-16 [17895432]. Nematode
    Factors are an extension of GenAge and GenDR.

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