Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    ATCAY ataxia, cerebellar, Cayman type ATCAY was found to be associated with longevity [21782286]. Human
    ATK1 v-akt murine thymoma viral oncogene homolog 1 ATK1 was found to be associated with longevity [21418511]. Human
    ATM ataxia telangiectasia mutated Individuals with ataxia-telangiectasia (AT) have a decreased lifespan, with a maximum of 52 years [3864931].ATM was found to be associated with longevity [22960875].ATM was found to be associated with longevity [20816691]. ATM was found to be associated with longevity [22960875]. ATM was found to be associated with longevity [22960875]. Human
    Atp5j2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2 Atp5j2 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    ATP8 ATP8 was found to be associated with longevity [10996007]. Human
    ATP8_RAT ATP synthase protein 8 ATP8_RAT is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    ATP9B ATPase, class II, type 9B ATP9B was found to be associated with longevity [21782286]. Human
    B9D2 + TGFB1 B9D2 + TGFB1 was found to be associated with longevity [15569360]. Human
    BAT5 abhydrolase domain containing 16A BAT5 was found to be associated with longevity [22279548]. Human
    Bbs1 Bardet-Biedl syndrome 1 protein Bbs1 is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    BDH1 3-hydroxybutyrate dehydrogenase, type 1 BDH1 was found to be associated with longevity [22445811]. Human
    BRCA1 breast cancer 1, early onset BRCA1 was found to be associated with longevity [11795532]. BRCA1 was found to be associated with longevity [11795532]. Human
    BRE brain and reproductive organ-expressed (TNFRSF1A modulator) BRE was found to be associated with longevity [22279548]. Human
    BTBD9 BTB (POZ) domain containing 9 BTBD9 was found to be associated with longevity [22533364]. Human
    BTG3 BTG family, member 3 BTG3 was found to be associated with longevity [22279548]. Human
    BTNL2 butyrophilin-like 2 (MHC class II associated) BTNL2 was found to be associated with longevity [22279548]. Human
    BUD31 BUD31 homolog (S. cerevisiae) BUD31 was found to be associated with longevity [21418511]. Human
    C2 complement component 2 C2 was found to be associated with longevity [22279548]. C2 was found to be associated with longevity [24244950]. Human
    C20orf79 chromosome 20 open reading frame 79 C20orf79 was found to be associated with longevity [22279548]. Human
    C3orf16 chromosome 3 open reading frame 16 C3orf16 was found to be associated with longevity [21418511]. Human
    C7orf50 chromosome 7 open reading frame 50 C7orf50 was found to be associated with longevity [22533364]. Human
    C8orf47 chromosome 8 open reading frame 47 C8orf47 was found to be associated with longevity [22445811]. Human
    C9orf11 chromosome 9 open reading frame 11 C9orf11 was found to be associated with longevity [22279548]. Human
    C9orf3 chromosome 9 open reading frame 3 C9orf3 was found to be associated with longevity [22279548]. C9orf3 was found to be associated with longevity [24244950]. Human
    C9orf94 ADAMTS-like 1 C9orf94 was found to be associated with longevity [22279548]. Human
    Factors are an extension of GenAge and GenDR.

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