| — | — | ENSRNOG00000044316 is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| — | — | ENSRNOG00000044070 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | SLC6A4 was found to be associated with longevity [15621215]. | Human |
| TAS2R16 | taste receptor, type 2, member 16 | TAS2R16 was found to be associated with longevity [23133589]. | Human |
| TUBB4B | tubulin, beta 2C | TUBB4B was found to be associated with longevity [22174011]. | Human |
| 16S rRNA | — | 16S rRNA was found to be associated with longevity [10996007]. | Human |
| 3p22-24 region | — | 3p22-24 region was found to be associated with longevity [22506048]. | Human |
| 3p24-22 | — | 3p24-22 was found to be associated with longevity [20824210]. | Human |
| 5HTT | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 5HTT was found to be associated with longevity [16095668]. | Human |
| 6q25-27 region | — | 6q25-27 region was found to be associated with longevity [22773346]. | Human |
| AAT | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | AAT was found to be associated with longevity [17048073]. AAT was found to be associated with longevity [17048073]. | Human |
| Abca2 | ATP-binding cassette sub-family A member 2 | Abca2 is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| ABCC4 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | ABCC4 was found to be associated with longevity [22533364]. | Human |
| ABL1 | c-abl oncogene 1, non-receptor tyrosine kinase | ABL1 was found to be associated with longevity [22445811]. | Human |
| AC000050.2 | — | AC000050.2 was found to be associated with longevity [22533364]. | Human |
| ACCN1 | amiloride-sensitive cation channel 1, neuronal | ACCN1 was found to be associated with longevity [22279548]. | Human |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829].
I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559].
I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238].
I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214].
Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. | Human |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | ACE was found to be associated with longevity [12954489]. | Human |
| ACE1 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | ACE1 was found to be associated with longevity [12954489]. | Human |
| ACPL2 | acid phosphatase-like 2 | ACPL2 was found to be associated with longevity [22445811]. | Human |
| ADA | adenosine deaminase | ADA was found to be associated with longevity [20174870]. ADA was found to be associated with longevity [21865054]. | Human |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | ADAMTS6 was found to be associated with longevity [22445811]. | Human |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | ADARB1 was found to be associated with longevity [20011587]. | Human |
| ADARB2 | adenosine deaminase, RNA-specific, B2 | ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. | Human |
| ADCY2 | adenylate cyclase 2 (brain) | ADCY2 was found to be associated with longevity [19641380]. | Human |
