Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Nematode « 
  • Classifications: + -
    Aging Associated (19)   Aging‑Suppressor (122)   Negative Aging‑Suppressor (103)   Positive Aging‑Suppressor (34)   Gero‑Suppressant (2)   Gerontogene (269)   Negative Gerontogene (6)   Positive Gerontogene (265)   DR‑Differential (3)   DR‑Induced (7)   DR‑Suppressed (2)   DR‑Essential (61)   DR‑Essential Ortholog (1)   DR‑Essential Paralog (2)   No Age Effect (52)  
  • Types: + -
    Gene (14)   Drug (1)   Protein coding (7)   miRNA (7)  
    • symbol name observation species
    C29F9.2 — RNA interference of C29F9.2 decreases median lifespan by 12% in wild type animals and 36% in daf-2 mutants [18006689]. Nematode
    tbc-7 TBC (Tre-2/Bub2/Cdc16) domain family RNA interference of tbc-7 decreased median lifespan by 28% in daf-2 mutants [18006689]. Nematode
    C32H11.1 — RNA interference of C32H11.1 extends lifespan [12845331]. Nematode
    C32H11.5 — RNA interference of C32H11.5 extends lifespan [15998808]. Nematode
    C33A12.1 — RNA interference of C33A12.1 increase mean lifespan by 40% [17608836]. Nematode
    C33F10.12 — RNA interference of C33H5.18 extends lifespan [15998808]. Nematode
    C33H5.18 — RNA interference of C33H5.18 decreases median lifespan by 44% in wild type animals, 77% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. Nematode
    C35A11.3 — RNA interference of C35A11.3 extends lifespan [15998808]. Nematode
    C36H8.1 — RNA interference of C36H8.1 extends lifespan [15998808]. Nematode
    scl-4 SCP-Like extracellular protein 4 RNA interference of scl-4 extends lifespan [15998808]. Nematode
    scl-8 SCP-Like extracellular protein 8 RNA interference of scl-8 increases mean lifespan 18% [17608836]. Nematode
    trim-9 TRIpartite Motif-containing protein homolog 9 RNA interference of trim-9 extends lifespan [15998808]. Nematode
    ttr-5 — RNA interference of ttr-5 increase mean lifespan 14% [17608836]. Nematode
    C42C1.3 — RNA interferenceof C42C1.3 increases mean lifespan by 60% [17608836]. Nematode
    C46G7.2 — RNA interference of C46G7.2 increases mean lifespan by 44% [17608836]. Nematode
    C47E12.2 — RNA interference of C47E12.2 increases mean lifespan by 36% [17608836]. Nematode
    C48E7.2 — RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. Nematode
    C56G2.1 — RNA interference of C56G2.1 in adulthood results in a 20% increase in mean lifespan [17411345]. Nematode
    calu-1 CALUmenin (calcium-binding protein) homolog RNA interference of calu-1 decreases median lifespan by 23% in a daf-2 background and 15% in daf-2/daf-16 double mutants [18006689]. Nematode
    cchl-1 Cytochrome C Heme-Lyase cchl-1 RNAi extends mean and maximum lifespan by 55% and 57%, respectively. Lifespan extension by RNAi of cchl-1 is not suppressed by daf-16 [12447374]. cchl-1 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    cco-1 Cytochrome C Oxidase RNA interference of cco-1 results in a 45-61% increase in mean lifespan (in fer-15; fem-1 and N2 background, respectively) [16103914]. RNAi against cco-1 increases mean and maximum lifespan by 73% and 90%, respectively [12471266]. cco-1 RNAi extends mean and maximum lifespan by 41 and 50%. RNAi of cco-1 during the larval stages is necessary and sufficient for increased lifespan, while only during the adulthood it fails to to extend lifespan. cco-1 RNAi results in reduced pharyngeal pumping, defecation, motility, and body size as well as reduced ATP levels (by 60-80%) and oxygen consumption. daf-16 mutation fails to prevent lifespan extenison by RNAi of cco-1 and mutation of daf-2 further extends the lifespan of cco-1 RNAi animals [12447374]. RNAi of cco-1 only during the adulthood increases mean and 75th %ile lifespan by 22-32 and 16-33%, respectively [22560223]. Nematode
    cco-2 Cytochrome C Oxidase 2 RNA interference of cco-2 results in a 53-57% increase in mean lifespan [16103914]. Nematode
    ccr-4 CCR (yeast CCR4/NOT complex component) homolog 4 RNA interference of ccr-4 decreases median lifespan by 33% in wild type animals, 37% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. Nematode
    cct-4 Chaperonin Containing TCP-1 4 RNA interference of cct-4 in adulthood results in a 28% increase in mean lifespan [17411345]. Nematode
    cct-6 Chaperonin Containing TCP-1 6 RNA interference cct-6 in adulthood results in a 20% increase in mean lifespan [17411345]. Nematode
    Factors are an extension of GenAge and GenDR.

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