SAM1 | S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) | Deletion of SAM1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. | Budding yeast |
CKA2 | CK2 subunit 2 | CKA2 deletion approximately doubles mean chronological lifespan under starvation/extreme DR in BY4741 also increases as well as as heat-shock resistance in SDC medium in the W303-1A and DBY746 genetic backgrounds [20657825]. | Budding yeast |
CKB2 | Casein Kinase Beta' subunit | Lack of Ckb2 promotes a modest but significant chronological lifespan extension and marked increase in yeat resistance [20657825]. | Budding yeast |
CUP9 | Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription | Deletion of CUP9 increases replicative lifespan by 30% in the alpha and a strains [18340043]. Although CPU9 was identified as a potential long-lived mutant strain in a bar-code screen, the chronological lifespan of CUP9 deletion mutant is not significantly different from than of wild-type under starvation/extreme DR [20657825]. | Budding yeast |
TRM9 | TRna Methyltransferase 9 | TRM9 deletion almost triples mean chronological lifespan under starvation/extreme DR, increases heat resistance, but reduces resistance to acetic acid. Similar effect were present in the BY746 background in SDC medium [20657825]. | Budding yeast |
RPL12B | Ribosomal Protein of the Large subunit 12B | Deletion of RPL12B increases mean replicative lifespan by 20% in the alpha strain [18423200] and by 22% in the remade strain, but increases non-significantly the mean replicative lifespan by 13% in the ORF collection [22377630]. RPL12B mutation promotes mean chronological longevity extension and heat-shock resistance but reduces acetic acid resistance under starvation/extreme DR. In DBY746 mutation of RPL12B almost doubles mean chronological lifespan in SDC medium and increases heat-shock resistance [20657825] | Budding yeast |
PMR1 | High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease | Deletion of PMR1 increses the replicative lifespan by 40% in the alpha strain and by 15% in the a strain. Overexpression of PMR1 extends the lifespan [21918615]. | Budding yeast |
BRE5 | BREfeldin A sensitivity 5 | Deletion of BRE5 increases mean replicative lifespan by 30% [16293764] and mean chronological lifespan in diploid cells [21447998] | Budding yeast |
CCR4 | Carbon Catabolite Repression 4 | Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. | Budding yeast |
CDC6 | Cell Division Cycle | The CDC6-1 conditional allele results in an approximately 20% increase in mean replicative life span. This allele is defective for replicative initiation form the rDNA ARS at 27 degree Celsius, resulting in a reduced rate of extrachromosomal rDNA circle accumulation [9428525]. The cdc6-1 allele results in genomic instability at the permissive temperature [8552037]. | Budding yeast |
GPA2 | G Protein Alpha subunit 2 | Deletion of GPA2 increases mean and maximum replicative lifespan by 40% and 26%, respectively [11000115]. Deletion of GPA2 extends replicative lifespan by reducing cAMP-PKA activity and provides a genetic model for DR [11000115]. | Budding yeast |
DNM1 | Dnm1p | Deletion of DNM1 extends significantly mean and maximum lifespan by 49 and 111% in FY10 strain and by 15 and 12% in BY4741 strain [17173038]. | Budding yeast |
RAS1 | — | Deletion in RAS1 increases mean (23%) and maximum (29%) replicative lifespan (in SP1) [8034612]. RAS1 deletion increases replicative lifespan by 15% in the alpha strain [19030232]. However, deletion of RAS1 slightly shortens chronological lifespan (in SP1) [12586694]. No lifespan extension results from overexpression of RAS1 (in SP1) [8034612]. | Budding yeast |
REI1 | Cytoplasmic pre-60S factor | REI1 deletion increases mean replicative lifespan by about 40% [16293764] in the alpha and a strains [19030232]. | Budding yeast |
ROM2 | RhO1 Multicopy suppressor 2 | Deletion of ROM2 increases mean replicative lifespan of the alpha strain by about 50% [16293764]. ROM deletion mutant replicative lifespan increases by 49% in the alpha strain and 16% in a strain. Deletion of ROM2 increases replicative lifespan by 38% in the alpha strain and by 29.3% in the a strain (34.2% in both) [19030232]. | Budding yeast |
RPL6B | Ribosomal Protein of the Large subunit 6B | Deletion of RPL6B significantly increases replicative lifespan [17174052]. Replicative lifespan increases by 15% in the alpha strain and 30-40% in a strain [19030232; 18340043; 18423200]. RPL6B deletion increases replicative lifespan by 30% [16293764]. | Budding yeast |
SCP1 | S. cerevisiae CalPonin 1 | Increasing actin dynamics by deletion of SCP1, encoding an actin bundling protein, increases replicative lifespan by 67% as well as chronological lifespan by 88%, whereas its overexpression leads to elevuated ROS levels and reduces chronological lifespan (in KAY446 strain) [15024029]. SCP1 is related to mammalian SM22/transgelin which is induced during senescence [9570922]. | Budding yeast |
SSD1 | Suppressor of SIT4 Deletion 1 | Overexpression of SSD1 (addition of a SSD1-V allele) increases replicative lifespan by 50%, independently of SIR2 and SIR2 further extends the lifespan, although SIR2 is necessary for SSD1-V cells to attain maximal lifespan [15126388]. SSD1-V also dramatically increases chronological lifespan with lifespan twice as long as ssd1-d cells [19570907]. Deletion of SSD1 increases replicative lifespan by 50% [Li et al., 2009].
Addition of SSD1-V allele to an ssd1-d strain suppresses the short lifespan of an MPT5 deletion mutant [11805047] and extend wild-type lifespan [Kaeberlein and Guarente, unpublished].
SSD1-V slightly extends the lifespan of swi4 and ccr4 mutant strains and suppresses the temperature sensitive growth phenotype of mpt5, ccr3, swi4, and swi6 single mutants [11805047]. SSD1-V also suppresses the synthetic lethality caused by deletion of MPT5 in combination with a mutation in SWI4, SWI6, or CCR4 [11805047]. SSD1-V suppresses mutations that affect cell wall stability [1545797; 8386319], RNA polymerase III activity [8510644], RNA splicing [10446233], and PKA activity [1848673; 8200529]. | Budding yeast |
URE2 | UREidosuccinate transport 2 | Deletion of URE2 increase mean replicative lifespan by 21-31% in BY4742 [16293764]. URE2 deletion increases replicative lifespan increased by 20% in the alpha strain [19030232]. | Budding yeast |
YBR238C | — | Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. | Budding yeast |
CPR7 | Cyclosporin-sensitive Proline Rotamase 7 | Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] | Budding yeast |
IRC14 | — | Deletion of IRC14 increases mean replicative lifespan by 14-22% [16293764].
IRC14 is a dubious ORF overlapping IDH2. | Budding yeast |
YDR248C | — | Deletion of YDR248C increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
YDR307W | — | Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
YER186C | — | Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |