| MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | rs282070 located in intron 1 of MAP3K7 gene was significantly associated with longevity in a Calabria (Italy) population.MAP3K7 was found to be associated with longevity [22576335]. | Human |
| GSTZ1 | glutathione transferase zeta 1 | rs21116999 located in intron 1 of the GSTZ1 gene was significantly associated with longevity in a population Calabria (Italy).GSTZ1 was found to be associated with longevity [22576335]. | Human |
| TP53 | tumor protein p53 | A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. | Human |
| FOXO3 | forkhead box O3 | FOXO3A gene polymorphism (rs3800231) may be important for achievement of longevity [22661237].FOXO3 was found to be associated with longevity [20884733]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [18765803]. FOXO3 was found to be associated with longevity [19196970]. FOXO3 was found to be associated with longevity [20849522]. FOXO3 was not found to be associated with longevity [20849522]. | Human |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | Males exhibit an age-related increase in the A-allele of rs2229765 and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age. In males +over 85 years, A/A homozygous individuals have the lowest plasma IGF-1 level. However, ther was no clear correlation between rs2229765 genotype and IGF-1 in females [19460140].IGF1 was found to be associated with longevity [20199671]. IGF1 was found to be associated with longevity [18761080]. IGF1 was found to be associated with longevity [18761080]. IGF1 was found to be associated with longevity [18761080]. IGF1 was not found to be associated with longevity [19489743]. | Human |
| APBB1 | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) | At least one copy of the minor allele of F65 was associated with decreased risk of sporadic dementia of the Alezheimer's type as suggest by a larde epidemiological study [9799084]. Fe65 protein binds to the intracellular domain of the beta-amyloid precursor protein and may modulate the internalization of betaPP. The deletion/substitution of the minor allele occurs with the intron that interrupts the two exons encoding the betaPP binding site. Linkage of the minor allele with resistance to DAT was confirmed in another study in populations over 75 years-of-age [11065130], while epidemiological studies that did not support the linage [11436125; 11099823; 11029529] lacked representation of individuals older than 75 years-old. Any protective effect that the minor allele of Fe65 might have is probably restricted to individuals older than 75 years. | Human |
| MTTP | microsomal triglyceride transfer protein | In a genome-wide scan for loci associated with exceptional longevity in 308 excpetinoal long-lived individuals (representing 17 sibships) a locus on chromosome 4 which maps to MTTP appears to be associated with long-lifespan in this group of subjects [11526246]. Siblings of centenarians are four times more likely to live into their 90s than control siblings [10326548]. Among a U.S.-based group of lon-lived individuals, there is a statistically significant under-representation of a risk allele of MTTP. These result was not replicated in a French-based longevity study, but this discrepancy could be due to a lack of statistically significance [11778046]. Howerver, another study failed to find a significant correlation between MTTP haplotype and longevity in1589 German nonagenarians, centenarians, and appropriately matched controls [15911777]. Neither the chromosomal loci nor MTTP were found to be associated with longevity in nonagenarian individuals in the Leiden Longevity study and Leiden 85-Plus Study [16611701]. Despite the lack of replication, humans homozysous for two on-functioning alleles of MTTP suffer from abetalipoproteinemia and lack of ApoB particles in serum. Also drugs that inhibit MTTP improve lipoprotein profiles.MTTP was found to be associated with longevity [16015282]. MTTP was found to be associated with longevity [17339647]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was found to be associated with longevity [16611701]. MTTP was not found to be associated with longevity [15911777]. MTTP was found to be associated with longevity [22496539]. | Human |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | The ER22/23EK variant of NR3C1 is correlated with longevity as well as relative gluccoritcoid resistance, greater insulin sensitivity, and lower total and low-density lipoprotein cholesterol levels in males [15276593].NR3C1 was found to be associated with longevity [22279548]. | Human |
| SIRT3 | sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) | The TT genotype of a silent G/T transition (G477T) in the SIRT3 gene was found to be correlated with longevity in males (but not females) in a study of individuals from Calabria, Italy [14580859]. | Human |
| SOD2 | superoxide dismutase 2, mitochondrial | The SOD2 rs2758331 has been correlated with exceptional longevity in a plethora of genetic signatures [22279548].SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [17903295]. SOD2 was found to be associated with longevity [15621215]. SOD2 was found to be associated with longevity [20003469]. SOD2 was found to be associated with longevity [19428448]. SOD2 was not found to be associated with longevity [9887369]. SOD2 was found to be associated with longevity [22279548]. SOD2 was not found to be associated with longevity [24163049]. | Human |
| TERC | telomerase RNA component | Mutations in TERC were overpresented in Ashkenazi centenarians [19915151].TERC was not found to be associated with longevity [22136229]. | Human |
| IL6 | interleukin 6 (interferon, beta 2) | Elevated IL-6 serum levels are associated with diseases, disability and mortality in the elderly. The proportion of homozyogtes for the G allele at -174 locus (a promoter genetic variability) decreases centenarian males, but not centenarians females. Only males, homozygous for the G allele at -174 locus have higher IL6- serum levels. Individuals who are genetically predisposed to produce high levels of IL-6 during aging (i.e. -174 locus GG homozygous men) are disadvantaged for longevity [11500818]. | Human |
| DRD4 | Dopamine D4 Receptor | DRD4 7R allele frequency is correlated with longevity. DRD4 moderates the impact of environments on behaviour and health. The oldest population have a 66% increase in individuals carrying the DRD4 7R allele relative to the younger ones and this genotype is strongly correlated with increased levels of physical activity [23283341].DRD4 was found to be associated with longevity [23283341]. DRD4 was found to be associated with longevity [15621215]. DRD4 was not found to be associated with longevity [15621215]. | Human |
| EXO1 | exonuclease 1 | The rs1776180 C allele in the promoter of EXO1 is significantly enriched in female Germans centenarians and this can be replicated in 445 female French centenarians. The C allele leads to the loss of binding site for the basic helix-loop-helix transcription factor E47, resulting in higher EXO1 expression [19698732].EXO1 was found to be associated with longevity [19698732]. EXO1 was not found to be associated with longevity [23770741]. | Human |
| MIR21 | MIRN21; hsa-mir-21; miR-21; miRNA21 | MIR21 is the most highly expressed microRNA gene in octogenarians and centenarians. MIR21 expression is higher under cardiovascular diseases and lower in centenarian offspring. MIR21 is correlated with C-reactive protein and fibrinogen levels. TGF-βR2 mRNA, a MIR21 target, exhibits the highest expression in leukocytes form a subset of octogenarians. MIR-21 may be a biomarker of inflammation [23041385]. | Human |
| APOC1 | apolipoprotein C-I | A polymorphism in the APOC1 gene is significantly associated with longevity [21740922].APOC1 was found to be associated with longevity [21740922].APOC1 was found to be associated with longevity [21740922]. APOC1 was found to be associated with longevity [9105559]. | Human |
| CETP | cholesteryl ester transfer protein, plasma | Homozygousity for the I405V variant of CETP is associated with exceptional longevity and larger HDL and LDL particle sizes as well as lower prevalence of hypertension, cardivascular disease, and metabolic disease among Askenazi Jews [14559957]. CETP I405V homozygousity is associated with exceptional longevity and preservation of cognitive function in Askenazi Jews [17190939].
V/V homozygotes tend to have a 9-23% CETP deficiency [9610775; 15243211]. A decrease in CETP function increases HDL (high density lipoproteins) levels in the body, and decreases LDL (low-density lipoprotein). The result of this s that HDL-c levels are approximately equal in individuals with the I/I or I/V genotypes, while there are ten percent higher in V/V individuals [9610775].
Therefore the V/V SNP acts kind like an endogenous *CEPT inhibitor*, which might be the responsible for the increase in longevity but may also have side effects.CETP was found to be associated with longevity [22336474].CETP was found to be associated with longevity [15621216].CETP was found to be associated with longevity [15888337]. CETP was found to be associated with longevity [22234866]. CETP was found to be associated with longevity [22336474]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [23389097]. CETP was found to be associated with longevity [15621216]. CETP was found to be associated with longevity [15888337]. CETP was not found to be associated with longevity [23389097]. CETP was found to be associated with longevity [14559957]. CETP was found to be associated with longevity [16602826]. CETP was found to be associated with longevity [23162014]. CETP was not found to be associated with longevity [14559957]. CETP was found to be associated with longevity [18034366]. CETP was not found to be associated with longevity [24468472]. | Human |
| PLXNA1 | plexin A1 | PLXNA1 is significantly associated with longevity [15105583]. | Human |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | M/T235 SNP in the AGT gene was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) and a significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele [11602206].AGT was found to be associated with longevity [15621215]. AGT was found to be associated with longevity [11602206]. AGT was not found to be associated with longevity [15621215]. | Human |
| APOA1 | apolipoprotein A-I | APOA1-MspI-RFLP (-75 nt from the transcription starting site) polymorphism was examined in a healthy population with 304 subjects aged 18-45 years, 267 subjects aged 46-80 years and 229 subjects aged 81-109 years (including 184 subjects, 43 males and 141 females, older than 100 years). The APOA1 allele P, which increases serum LDL-C at middle-age and is over-represented in cardiovascular diseases, tends to increase its frequency in the centenarians males [12556235].APOA1 was found to be associated with longevity [12556235]. | Human |
| APOA4 | apolipoprotein A-IV | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. | Human |
| APOB | apolipoprotein B (including Ag(x) antigen) | A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms. Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls [9050915].apoB was found to be associated with longevity [17393087].APOB was found to be associated with longevity [15028112]. APOB was found to be associated with longevity [17393087]. APOB was not found to be associated with longevity [17393087]. APOB was found to be associated with longevity [9050915]. APOB was not found to be associated with longevity [11592926]. APOB was not found to be associated with longevity [8018664]. APOB was not found to be associated with longevity [9050915]. | Human |
| AKAP10 | A kinase (PRKA) anchor protein 10 | Male (n= 4766) and female (n = 6202) divided into young (183-9 years) and old (60 years) groups were examined for polymorphisms. A polymorphism that results in an amino acid change from Ile to Val showed the strongest correlation with age. The Val variant was associated with a statistically significant decrease in the length of the electrocardiogram PR interval. An A to G polymorphism in the 3'UTR of D-AKAP2 showed a significant decrease of the G allele in the older sample of both genders. Additionally, the I646V polymorphism was found to be significantly different between young and old in both males and females [12646697]. | Human |
| CPB2 | carboxypeptidase B2 (plasma) | Genotypes of the CPB2 gene were studied in 2224 men and women aged 65 or older at baseline. During 10 years of follow-up, men with the -438 A/A genotype had decreased mortality due to all causes, and lived, on average, longer than men with the -438 G allele. The effects of -438 G/A in women were smaller and not statistically significant [15939070].CPB2 was found to be associated with longevity [15939070]. | Human |
| F7 | coagulation factor VII (serum prothrombin conversion accelerator) | Blood coagulation factor VII (FVII) R/Q353 and FVII-323ins10 SNPs were examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years). R/Q353 and FVII-323ins10 manifest significant influences on survival in males, with reduced hazards of death for carriers of the Q353 allele and the FVII-323P10 allele [11602206].F7 was found to be associated with longevity [15621215]. F7 was found to be associated with longevity [10744171]. F7 was found to be associated with longevity [10744171]. F7 was found to be associated with longevity [11602206]. | Human |
