| Cct1 | CTP:phosphocholine cytidylyltransferase 1 | Overexpression of Cct1 from a doxycycline-inducible promoter results in a 6 - 8% increase in mean lifespan (in the PdL x rtTA; Oregon-R x rtTA strain) [12620118].
Cct1 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages beyond the day of eclosion [23106705]. | Fruit fly |
| InR | Insulin-like 1 receptor | Mutations in InR (InRE19/InRp5545 transheterozygous) result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality (although no significant change in lifespan) [11292875]. InrGC25/InrE19 transheterozygous animals are short-lived an exhibit an elevated rate of age-independent mortality [11292874].
Natural allelic variation in InR are associated with variation in lifespan [15013662; 20074316]. | Fruit fly |
| CLU | clusterin | Overexpression of the secretory form of human Clusterin in fruit flies increases mean lifespan. hClu overexpression flies also have greater tolerance to heat shock, wet starvation, and oxidative stress and the whole body amounts of reactive oxygen species is lower [22465014].CLU was found to be associated with longevity [16804001]. | Fruit fly |
| Fhos | — | Fhos exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Fhos is upregulated under microbial infection [12431377] and downregulated with age [17196240]. | Fruit fly |
| CG4726 | — | CG4726 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6041 | — | CG6041 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG6048 | — | CG6048 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| fs(1)M3 | female sterile (1) M3 | fs(1)M3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
| Ten-a | Tenascin accessory | Ten-a exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the head in for longevity selected lines [23106705]. | Fruit fly |
| CG12004 | — | CG12004 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG6511 | — | CG6511 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| Prm | Paramyosin | Prm exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705]. | Fruit fly |
| CG13306 | — | CG13306 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| CG34426 | — | CG34426 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. | Fruit fly |
| Doc3 | Dorsocross3 | Doc3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Gain-of-function mutation in Doc3 causes delay of age-related motor impairment [19481596].
| Fruit fly |
| CG5194 | — | CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
| Doc1 | — | Doc1 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705].
| Fruit fly |
| Tequila | — | Tequila exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Tequila is upregulated with age and microbial infection, while downregulated with oxidative stress [11095759; 17196240; 15475297].
| Fruit fly |
| Psa | Puromycin sensitive aminopeptidase | Psa exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages except 50 days [23106705]. Experimental u-regulation of Psa protects against tau-induced neurodegeneration [16950154]. | Fruit fly |
| CG12090 | — | CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| CG7852 | — | CG7852 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head and abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
| CG13917 | — | CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
| dro2 | drosomycin-2 | dro2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
| dro4 | drosomycin-4 | dro4 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
| CG12016 | — | CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
