Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    mtDNA
    Fhos Fhos exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fhos is upregulated under microbial infection [12431377] and downregulated with age [17196240]. Fruit fly
    CG4726 CG4726 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG6041 CG6041 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG6048 CG6048 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    fs(1)M3 female sterile (1) M3 fs(1)M3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG6511 CG6511 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG13306 CG13306 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    CG34426 CG34426 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    Doc3 Dorsocross3 Doc3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Gain-of-function mutation in Doc3 causes delay of age-related motor impairment [19481596]. Fruit fly
    CG5194 CG5194 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Fruit fly
    Tequila Tequila exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705]. Tequila is upregulated with age and microbial infection, while downregulated with oxidative stress [11095759; 17196240; 15475297]. Fruit fly
    CG12004 CG12004 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG12090 CG12090 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG7852 CG7852 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head and abdomen of animals that were selected for longevity [23106705]. Fruit fly
    CG13917 CG13917 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG12016 CG12016 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    kst karst kst exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it has three differentially expressed transcripts in head of animals that were selected for longevity [23106705]. Fruit fly
    Ten-a Tenascin accessory Ten-a exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the head in for longevity selected lines [23106705]. Fruit fly
    LanB2 Laminin B2 LanB2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    CG16711 CG16711 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    Doc1 Doc1 exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705]. Fruit fly
    CG4942 CG4942 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    Prm Paramyosin Prm exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705]. Fruit fly
    CG32022 CG32022 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. Fruit fly
    • Page 1 of 24
    • 25 of 584 factors
    Factors are an extension of GenAge and GenDR.

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