| IMD2 | IMP Dehydrogenase 2 | Deletion of IMD2 does non-significantly decrease mean replicative lifespan by 1% and non-significantly increased maximum replicative lifespan by 21% [20550517]. | Budding yeast |
| GCN4 | Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels | Deletion of GCN4 increases the replicative lifespan by 10% in the alpha strain [19030232].
GCN4 deletion decreases the lifespan in the alpha and a strain [20657825].
The chronological lifespan of GCN4 deletion is strongly decreased in the a strain [20421943]. | Budding yeast |
| kri-1 | human KRIT 1 (Krev interaction trapped/cerebral cavernous malformation 1) homolog | RNA interference suppresses glp-1 life-extension but does not shorten lifespan of wildtype strains. kri-1(ok1251) mutation does not shorten the lifespan significantly [22560223]. | Nematode |
| Y59A8B.2 | — | RNA interference decreased median lifespan by 59% in daf-2 mutants. | Nematode |
| daf-12 | Abnormal DAuer Formation | Mutations in daf-2 and daf-12, but not mutations in daf-12 alone, nearly quadruples lifespan [7789761]. Recessive loss of function mutation in daf-12 shortens lifespan. daf-12 activity is required for lifespan extension after germ line ablation [10360574]. daf-12 mutation suppresses the lifespan extension by mutation in daf-28 [8807293]. daf-12 mutants are dauer defective and heterochronic [7219552]. Some daf-12 alleles exhibit synthetic lethality with mutation of age-1 [8807293] or daf-12 [1732156]. | Nematode |
| tbc-7 | TBC (Tre-2/Bub2/Cdc16) domain family | RNA interference of tbc-7 decreased median lifespan by 28% in daf-2 mutants [18006689]. | Nematode |
| Y46G5A.6 | phi-3 | RNA interference of Y46G5A.6 in adulthood shortens the extends lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms occurs by knockdown of Y46G5A.6 [17392428]. | Nematode |
| NAC | N-acetyl cysteine | Treatment with 10 mM of NAC has no effect on the lifespan of wild-type, but fully abolishes the increased longevity of nuo-6 and severly limits that of isp-1. At high concentration (> 10-15 nM) NAC can be become deleteroius even on the wild-type [21151885]. | Nematode |
| unc-51 | UNCoordinated-51 | unc-51(e369) mutation reduces mean but extends maximum lifespan. unc-51(e369) mutation reduces lifespan of eat-2(ad1116) mutants to that of wild-type [18219227]. | Nematode |
| tps-1 | Trehalose 6-Phosphate Synthase 1 | RNA interference mediated inactivation of the trehalose-biosynthetic gene trehalose-6-phosphate synthase-1 (tps-1) decreases daf-2 mutant's long lifespan [20477758]. | Nematode |
| tps-2 | Trehalose 6-Phosphate Synthase 2 | RNA interference mediated inactivation of the trehalose-biosynthetic gene trehalose-6-phosphate synthase-2 (tps-2) decreases daf-2 mutant's long lifespan [20477758]. | Nematode |
| sbds-1 | Shwachman-Bodian-Diamond Syndrome protein homolog 1 | RNA interference of sbds-1 decreases median lifespan by 24% in daf-2 mutants [18006689]. RNAi knockdown of sbds-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. SBDS-1 are elevated in eat-2 mutants. Increased content of SBDS-1 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| dcp-66 | Deacetylase Complex Protein 66 | dcp-66 RNAi shortens the mean lifespan by 29% and suppresses lifespan extension by isp-1 mutation, but does not significantly affect lifespan extension neither by eat-2 nor daf-2 mutation [22829775]. | Nematode |
| baf-1 | Barrier to Autointegration Factor 1 | RNA interference of baf-1 decreases median lifespan by 28% in daf-2 mutants [18006689]. | Nematode |
| mdt-26 | MeDiaTor 26 | RNA interference of mdt-26 decreases the median lifespan 42% in daf-2 long-lived mutants [18006689]. | Nematode |
| C29F9.1 | — | RNA interference of C29F9.1 decreases median lifespan by 35% in daf-2 mutants [18006689]. | Nematode |
| cit-1.2 | CyclIn T 1.2 | RNA interference cit-1.2 decreases median lifespan by 27% in daf-2 mutants [18006689]. | Nematode |
| cul-1 | CULlin 1 | RNAi of cul-1 decreases lifespan of daf-2 mutant, but not of wild-type or glp-1 mutant. The CUL-1 complex functions in postmitotic, adult somatic tissues of insulin/insulin-like growth factor-1-signaling mutants to enhance longevity. It may act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO [17392428]. | Nematode |
| cku-70 | Caenorhabditis KU 70 | RNA interference of cku-70 further increases the lifespan of daf-2 mutants. Lifespan of daf-16 mutants is slightly decreased by cku-70 RNAi [16099946]. | Nematode |
| let-4 | LEThal 4 | let-4 (alias sym-5) is downregulated in space.
RNA intereference of let-4 extends mean and 75%ile lifespan by 4%, but reduces maximum lifespan by 25% [22768380]. | Nematode |
| Vitamin C | — | Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].
Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628]. | Nematode |
| sgg | shaggy | Several insertions of P-based vectors in the structural part of sgg are associated with alterations of male and female lifespan [22661237]. | Fruit fly |
| Trxr-1 | Thioredoxin reductase-1 | Overexpression of Trxr-1 (alias GSR; glutathione reductase) in transgenic flies results in increased lifespan and oxidative stress resistance, but only under hyperoxia [10506576]. | Fruit fly |
| mir-34 | — | mir-34 loss triggers a gene expression profile of accelerated brain aging, late-onset brain degeneration and catastrophic decline in survival, while mir-34 upregulation extends median lifespan and mitigated neurodegeneration induced by polyglutamine. | Fruit fly |
| tert | telomerase reverse transcriptase | First-generation tert(-/-) zebrafish die prematurely with shorter telomeres. tert(-/-) fish develop degenerative phenotypes, including premature infertility, gastrointestinal atrophy, and sarcopenia. tert(-/-) mutants have impaired cell proliferation, accumulation of DNA damage markers, and a p53 response leading to early apoptosis, followed by accumulation of senescence cells. Apoptosis is primarily observed in the proliferative niche and germ cells. Cell proliferation, but not apoptosis, is rescued in tp53(-/-)tert(-/-) mutants, underscoring p53 as mediator of telomerase deficiency and consequent telomere instability [http://denigma.de/url/3p]. | Zebrafish |
