Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    MT-ND2 Human
    SlC13A5 solute carrier family 13 (sodium-dependent citrate transporter), member 5 Human
    HSPA4 heat shock 70kDa protein 4 Human
    APOE E4 Human
    LASS1 LAG1 homolog, ceramide synthase 1 Human
    HLA major histocompatibility complex, class II, DR beta 1 Human
    Foxo3 House mouse
    PAI-1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Human
    F2 Coagulation factor II (thrombin) Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    ADIPOQ adiponectin, C1Q and collagen domain containing Human
    Interleukin 6 IL-6 House mouse
    CYBA Human
    YBX2 Y box binding protein 2 Human
    CDKN2B Human
    MT-ATP6 Human
    RAGE Human
    ND3 Human
    CO3 vascular endothelial growth factor A Human
    ND3 Human
    ND4 Human
    ND5 Human
    MT-CYB Human
    Factors are an extension of GenAge and GenDR.

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