| INSR | insulin receptor | 5 intronic and 1 exonic polymorphisms in the INSR gene were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33). One haplotype, which was comprised of 2 intronic SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls [15582274].INSR was found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [19489743]. | Human |
| TP53 | tumor protein p53 | A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. | Human |
| APOB | apolipoprotein B (including Ag(x) antigen) | A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms. Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls [9050915].apoB was found to be associated with longevity [17393087].APOB was found to be associated with longevity [15028112]. APOB was found to be associated with longevity [17393087]. APOB was not found to be associated with longevity [17393087]. APOB was found to be associated with longevity [9050915]. APOB was not found to be associated with longevity [11592926]. APOB was not found to be associated with longevity [8018664]. APOB was not found to be associated with longevity [9050915]. | Human |
| IGF2 | insulin-like growth factor 2 (somatomedin A) | A/G ApaI site SNP in the IGF2 gene was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years). An increase in the A allele was observed in older Ashkenazi females and a highly significant increase was observed in the AA genotype in these subjects [15621215].IGF2 was found to be associated with longevity [19367319]. IGF2 was not found to be associated with longevity [19367319]. IGF2 was found to be associated with longevity [17989723]. IGF2 was found to be associated with longevity [15621215]. | Human |
| ADARB2 | adenosine deaminase, RNA-specific, B2 | ADARB2 was found to be associated with longevity [20011587]. ADARB2 was not found to be associated with longevity [20011587]. | Human |
| ADIPOQ10 | adiponectin, C1Q and collagen domain containing | ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [23339001]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was found to be associated with longevity [18511746]. ADIPOQ was not found to be associated with longevity [18765803]. | Human |
| ADIPQO | adiponectin, C1Q and collagen domain containing | ADIPQO was not found to be associated with longevity [20201642]. ADIPQO was found to be associated with longevity [20201642]. | Human |
| ADRB2 | adrenergic, beta-2-, receptor, surface | ADRB2 was found to be associated with longevity [23020224]. ADRB2 was not found to be associated with longevity [23020224]. | Human |
| AGTR1 | angiotensin II receptor, type 1 | AGTR1 was found to be associated with longevity [22569962]. AGTR1 was not found to be associated with longevity [22569962]. | Human |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 | AKT1 was found to be associated with longevity [19489743]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was found to be associated with longevity [22929028]. AKT1 was not found to be associated with longevity [22929028]. | Human |
| HFE | hemochromatosis | C282Y, H63D and S65C polymorphisms in the HFE gene were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women). A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people [11857056].HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [12714263]. HFE was not found to be associated with longevity [11857056]. HFE was not found to be associated with longevity [12714263]. | Human |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | CDKN1A was found to be associated with longevity [20126416]. CDKN1A was found to be associated with longevity [20126416]. CDKN1A was not found to be associated with longevity [20126416]. | Human |
| CDKN2B-AS1 | CDKN2B antisense RNA 1 | CDKN2B-AS1 was found to be associated with longevity [24163049]. CDKN2B-AS1 was not found to be associated with longevity [24163049]. | Human |
| CLU | clusterin | CLU was found to be associated with longevity [16804001]. CLU was not found to be associated with longevity [22445811]. | Human |
| DEAF1 | deformed epidermal autoregulatory factor 1 (Drosophila) | DEAF1 was found to be associated with longevity [19367319]. DEAF1 was found to be associated with longevity [19367319]. DEAF1 was found to be associated with longevity [19367319]. DEAF1 was not found to be associated with longevity [19367319]. | Human |
| GSTT1 | glutathione S-transferase theta 1 | Deletion in the GSTT1 was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age. A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects [11162685].GSTT1 was found to be associated with longevity [11162685]. GSTT1 was found to be associated with longevity [16574194]. GSTT1 was not found to be associated with longevity [11162685]. GSTT1 was not found to be associated with longevity [15195682]. | Human |
| Downstream of FOXO3A | — | Downstream of FOXO3A was found to be associated with longevity [19196970]. Downstream of FOXO3A was not found to be associated with longevity [19196970]. | Human |
| DRD4 | Dopamine D4 Receptor | DRD4 7R allele frequency is correlated with longevity. DRD4 moderates the impact of environments on behaviour and health. The oldest population have a 66% increase in individuals carrying the DRD4 7R allele relative to the younger ones and this genotype is strongly correlated with increased levels of physical activity [23283341].DRD4 was found to be associated with longevity [23283341]. DRD4 was found to be associated with longevity [15621215]. DRD4 was not found to be associated with longevity [15621215]. | Human |
| ESR1 | estrogen receptor 1 | ESR1 was found to be associated with longevity [20819792]. ESR1 was found to be associated with longevity [20599431]. ESR1 was found to be associated with longevity [20819792]. ESR1 was found to be associated with longevity [20819792]. ESR1 was not found to be associated with longevity [20599431]. | Human |
| INS | insulin | Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. INS was found to be associated with longevity [22406557; 19367319; 17989723; 19489743]. | Human |
| FAS | Fas (TNF receptor superfamily, member 6) | FAS was not found to be associated with longevity [11965496]. FAS was found to be associated with longevity [22279548]. | Human |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | FCGR2A was found to be associated with longevity [16893392]. FCGR2A was not found to be associated with longevity [16893392]. | Human |
| FOXO1A | forkhead box O1 | FOXO1A was found to be associated with longevity [17903295]. FOXO1A was found to be associated with longevity [17903295]. FOXO1A was not found to be associated with longevity [19489743]. | Human |
| FOXO3 | forkhead box O3 | FOXO3A gene polymorphism (rs3800231) may be important for achievement of longevity [22661237].FOXO3 was found to be associated with longevity [20884733]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [19793722]. FOXO3 was found to be associated with longevity [18765803]. FOXO3 was found to be associated with longevity [19196970]. FOXO3 was found to be associated with longevity [20849522]. FOXO3 was not found to be associated with longevity [20849522]. | Human |
| FOXO3A | forkhead box O3 | FOXO3A was found to be associated with longevity [19415983]. FOXO3A was found to be associated with longevity [20849522]. FOXO3A was found to be associated with longevity [19489743]. FOXO3A was found to be associated with longevity [21418511]. FOXO3A was not found to be associated with longevity [19489743]. FOXO3A was found to be associated with longevity [19196970]. FOXO3A was found to be associated with longevity [25038186]. FOXO3A was not found to be associated with longevity [25038186]. | Human |
