Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
  • symbol name observation species
    Intergenic (upstream of C4orf17) Intergenic (upstream of C4orf17) was found to be associated with longevity [14615589]. Human
    rs12413082 Human
    rs7915479 Human
    rs1556758 Human
    B9D2 + TGFB1 B9D2 + TGFB1 was found to be associated with longevity [15569360]. Human
    rs2073586 Human
    rs11237644 Human
    Downstream of LACE1 Downstream of LACE1 was not found to be associated with longevity [19196970]. Human
    rs870959 Human
    upstream of FOXO3A upstream of FOXO3A was found to be associated with longevity [19196970]. Human
    rs6592810 Human
    Upstram of FOXO3A Upstram of FOXO3A was found to be associated with longevity [19196970]. Human
    rs4938180 Human
    Downstream of FOXO3A Downstream of FOXO3A was found to be associated with longevity [19196970]. Downstream of FOXO3A was not found to be associated with longevity [19196970]. Human
    rs2111173 Human
    rs969845 Human
    rs9315385 Human
    rs2147556 Human
    rs731287 Human
    rs285097 Human
    rs1584547 Human
    rs4594173 Human
    rs2277472 Human
    rs10134056 Human
    rs4777170 Human
    Factors are an extension of GenAge and GenDR.

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