| YBR225W | — | Deletion of YBR225W decreases replicative lifespan by 40% in the alpha strain [19030232]. | Budding yeast |
| ISC1 | Inositol phosphoSphingolipid phospholipase C 1 | ISC1 deletion decreases chronological lifespan [21707788; 21707788]. CTA1
overexpression partially suppresses the shortened lifespan by ISC1. Deletion of SIT4 totally rescues the short lifespan of ISC1 mutants [21707788]. HOG1 deletion partially suppresses the premature aging phenotype and short lifespan of ISC1 deletion [22445853]. | Budding yeast |
| RIF1 | RAP1-Interacting Factor 1 | Deletion of RIF1 decrease replicative lifespan by 40% [9275199]. RIF1 deletion increases telomere silencing and length [8319907; 1577274], and therefore likely recruits SIR2 from rDNA to the telomeres which result in lifespan shortening. The sir4-42 allele suppresses the short lifespan of a RIF1 mutant [9275199]. | Budding yeast |
| VHS1 | Viable in a Hal3 Sit4 background 1 | Deletion of VHS1 increases replicative lifespan [16293764]. VHS1 deletion increases replicative lifespan by 60% in the alpha strain [19030232]. | Budding yeast |
| ETR1 | 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis | Replicative lifespan decreased by 45% in the a strain | Budding yeast |
| SGF73 | 73 kDa subunit of SAGA histone acetyltransferase complex; involved in formation of the preinitiation complex assembly at promoters | Strongly reduced chronological lifespan | Budding yeast |
| BPT1 | ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p | Replicative lifespan increased by 20% in the alpha strain | Budding yeast |
| ACH1 | Acetyl CoA Hydrolase 1 | ACH1 deletion cells accumulate a high amount of extracellular acetic acid and display a reduced mean and maximum chronological lifespan. Maximum lifespan is reduced by 32%. Lifespan shortening is completely abrogated by alleviating the acid stress either by a DR regimen that prevents acetic acid production or by transferring chronologically aging mutant cells to water. Deletion of ACH1 is accompanied by reactive oxygen species accumulation, severe mitochondrial damage, and an early insurgence of apoptosis [22754872]. | Budding yeast |
| ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions | Replicative lifespan decreased by 70% in the alpha strain | Budding yeast |
| ATH1 | Acid TreHalase | Deletion of ATH1 extend the mean chronological lifespan by 17% (at 30 degree Celsus in BY4742) [22783207].
ATH1 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. | Budding yeast |
| ACO1 | ACOnitase 1 | Deletion of ACO1 decreases mean chronological lifespan by 42 - 56% in diploid cells [21447998]. | Budding yeast |
| ACO2 | ACOnitase 2 | Deletion of ACO2 increases replicative lifespan by 20% in the alpha strain and decreases it by 10% in the a strain [18340043]. Its deletion increases mean chronological lifespan by 6 - 44% (6, 22, 20, 20, 19, 44) in diploid cells [21447998]. | Budding yeast |
| ACT | ACTin | An ACT1 allele which reduces actin dynamics decreases chronological lifespan, while an allele that increases actin dynamics increases chronological lifespan by 32% [15024029]. | Budding yeast |
| ABP1 | Actin Binding Protein 1 | ABP1 deletion increases replicative lifespan by 30% in the alpha strain and decreases replicative lifespan by 20% in the a strain [18340043]. Deletion of ABP1 increases replicative lifespan by 20% in the alpha strain and decreases replicative lifespan by 20% in the a strain [19030232]. | Budding yeast |
| APD1 | Actin Patches Distal 1 | Although APD1 was identified as a potential long-lived mutant strain in a bar-code screen, deletion of APD1 does not significantly affect chronological lifespan under starvation/extreme DR [20657825]. | Budding yeast |
| BUD6 | Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate [Saccharomyces cerevisiae] | Early buds have increased lifespan while 8th and 12th generation daughters have decreased lifespans | Budding yeast |
| ARP1 | Actin-Related Protein 1 | Deletion of ARP1 decreases replicative lifespan by 40% in the alpha strain [18340043; 19030232]. | Budding yeast |
| ACB1 | Acyl-CoA-Binding 1 | ACB1 deletion extends chronological lifespan under starvation/extreme DR. Similar heat-shock resistance and resistance to a very hight concentration of acetic acid (but not resistance to oxidative stress) was enhanced by the deletion of ACB1. Deletion of ACB1 in W303-1A and DBY746 genetic backgrounds on synthetic complete media causes severe growth defects and sightly shorter lifespan and also heat-sensitivity [20657825]. | Budding yeast |
| ADE3 | ADEnine requiring 3 | Deletion of ADE3 increases chronological lifespan [20421943]. | Budding yeast |
| ADE4 | ADEnine requiring 4 | ade4 mutation extends chronological lifespan, but not replicative lifespan, and is non-additive with 0.5% glucose or amino-acid DR on chronological lifespan extension. ADE4 deletion in atg16 mutants results only in a partial extension of the chronological lifespan by 0.5% glucose DR [20421943]. | Budding yeast |
| AVO2 | Adheres VOraciously (to TOR2) | Deletion of AVO2 extends chronological lifespan [21641548]. | Budding yeast |
| ADH1 | Alcohol DeHydrogenase 1 | Deletion of ADH1 increases replicative lifespan by 20% in the alpha strain and 15% in the a strain [18340043]. Adh1 is oxidatively modified during aging and its activity becomes reduced. Overexpression of ADH1 by introducing and extra copy increases mean replicative lifespan by 30% as well as slightly chronological lifespan and was associated with increased Sir2 activity [17975074]. | Budding yeast |
| ADH2 | Alcohol DeHydrogenase 2 | Deletion of ADH2 increases mean chronological lifespan by 6 - 57% (6, 17, 57) in diploid cells [21447998]. | Budding yeast |
| ADH3 | Alcohol DeHydrogenase 3 | Deletion of ADH3 decreases mean chronological lifespan by 15% [21447998]. | Budding yeast |
| ATP3 | Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated | Chronological lifespan increased up to 50% | Budding yeast |
