| Intergenic (downstream of SSBP3 and MRPL37) | — | Intergenic (downstream of SSBP3 and MRPL37) was found to be associated with longevity [21418511]. | Human |
| F59B2.8 | — | RNA interference in adulthood shortened the extended lifespan of daf-2(mu150) mutants. Only a negligible or small reduction in the lifespan of wild-type worms was observed in knockouts. | Nematode |
| ZK686.2 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| YIA6 | — | Deletion of YIA6 decreases replicative lifespan by 30% in the a strain [18340043]. | Budding yeast |
| F59B8.2 | — | RNA interference resulted in extended lifespan. | Nematode |
| RAD27 | — | Deletion of RAD27 results in signs of premature aging and approximately 60% reduction in mean replicative lifespan [12024027]. | Budding yeast |
| ZK809.3 | — | RNA interference increased mean lifespan by 100%. | Nematode |
| YKL069W | — | Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. | Budding yeast |
| Wrn | — | Mice lacking the helicase domain of the WRN ortholog exhibit many phenotypic features of Werner Syndrom, including a pro-oxidant status and a shorter mean lifespan. Mice with a deletion in the helicase domain [9789047] recapitulates most of the Werner syndrome phenotypes, including an abnormal hyaluronic acid excretion, higher reactive oxygen species levels, dyslipidemia, increased genomic instability, and cancer incidence. Wrn(Dehl/Dehl) mutant mice have a 10 - 15% decrease in their mean lifespan [12707040; 19741171]. | House mouse |
| F59C6.5 | — | RNA interference in adulthood extended mean lifespan by 19%. | Nematode |
| RAD57 | — | Mutations result in a 40% reduced lifespan. | Budding yeast |
| F54D5.11 | — | F54D5.11 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ND2 | — | ND2 was found to be associated with longevity [10996007]. | Human |
| rs2495513 | — | — | Human |
| Ash-2 | — | RNAi extended fertile lifespan. | Nematode |
| YLR422W | — | Deletion of YLR422W increases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| F54D5.11 | — | F38E11.5 RNAi in the adulthood extends the lifespan [New longevity regulators]. | Nematode |
| ATP8 | — | ATP8 was found to be associated with longevity [10996007]. | Human |
| rs4291539 | — | — | Human |
| Rbr-2 | — | RNAi decreased lifespan. | Nematode |
| HSC80 | — | Deletion of HSC82 has no effect on replicative lifespan, but shortens chronological lifespan [11361336]. | Budding yeast |
| 16S rRNA | — | 16S rRNA was found to be associated with longevity [10996007]. | Human |
| rs10923806 | — | — | Human |
| cul-6 | — | RNAi decrease lifespan of daf-2 mutant and increased lifespan glp-1 mutant, but had no significant effect on lifespan of WT. | Nematode |
| APOE + TOMM40 | — | APOE + TOMM40 was not found to be associated with longevity [21418511]. APOE + TOMM40 was not found to be associated with longevity [23040522]. | Human |
