| YDR307W | — | Deletion of YDR307W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| R02D3.3 | — | R02D3.3 RNAi in the adulthood extends mean and maximum lifespan by 13 and 22%, respectively [23144747]. | Nematode |
| mir-239 | — | Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively, whereas overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Nematode |
| F55B11.3 | — | RNA interference extends lifespan. | Nematode |
| YER186C | — | Deletion of YER186C increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| F55B11.5 | — | RNA interference extends lifespan. | Nematode |
| R05A10.5 | — | RNA interference extended lifespan. | Nematode |
| ZC132.3 | — | RNA interference in adulthood extended mean lifespan by 26%. | Nematode |
| YER187W | — | Deletion of YER187W increases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
| mir-58 | — | mir-58(n4640) mutation decreases the mean lifespan by 20% [22482727]. | Nematode |
| F55B12.4 | — | RNA interference decreased median lifespan by 52% in wild type animals, 44% in a daf-2 background and 14% in daf-2/daf-16 double mutants. | Nematode |
| R08E3.3 | — | RNA interference extended lifespan. | Nematode |
| ZC250.3 | — | RNA interference decreased median lifespan by 29% in wild type animals, 41% in a daf-2 background and 25% in daf-2/daf-16 double mutants. | Nematode |
| R10H10.7 | — | RNA interference increased mean lifespan by 22%. | Nematode |
| YGL235W | — | YGL235W increases replicative lifespan by 20% in the alpha strain [19030232]. | Budding yeast |
| F56D5.5 | — | RNA interference increased mean lifespan by 20%. | Nematode |
| YGR071C | — | Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. | Budding yeast |
| F57B10.3 | — | RNA interference against F57B10.3 extends mean and maximum lifespan by 21% and 48%, respectively, without causing any developmental pleiotropies or defects in mitochondrial morphology. Lifespan extension by F57B10.3 is suppressed by daf-16. F57B10.3 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
| ZK1127.5 | — | RNA interference in adulthood extended mean lifespan by 24%. | Nematode |
| YGR130C | — | Deletion of YGR130C increases replicative lifespan increased by 30% in the alpha strain and increased by 20% in the a strain [18340043], as well as mean and maximum chronological lifespan by 18 and 50%, respectively [22216232] | Budding yeast |
| R12B2.6 | — | RNA interference decreased median lifespan by 22% in wild type animals and 24% in daf-2 mutants. | Nematode |
| F59A3.3 | — | RNA interference in adulthood resulted in a 14% mean lifespan extension. | Nematode |
| R53.4 | — | RNA interference in adulthood extended mean lifespan by 20%. | Nematode |
| ANS1 | — | Deletion of ANS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
| mir-124 | — | Loss of mir-124 increases reactive oxygen species formation and accumulation of the aging marker lipofuscin, reduces whole body ATP levels and results in reduction in lifespan [23075628].
Supplementation of vitamin C normalizes the reduced median lifespan of mir-124 mutants [23075628].
The expression of the conserved mir-124 in whole wrn-1 mutants (which premature age) is significantly reduced [23075628]. | Nematode |
