gsa-1 | — | RNAi against R06A10.2 decreases mean and maximum lifespan by 83-85% and 48%, respectively [18059442]. | Nematode |
Y47D3A | — | RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. | Nematode |
pas-1 | — | RNAi against pas-1 started after the animal reached the late L4 stage decreases mean lifespan by 18-19% [22103665]. RNAi pas-1 decreases lifespan of daf-2 mutant, but not of WT or glp-1 mutant [17392428]. | Nematode |
HSC80 | — | Deletion of HSC82 has no effect on replicative lifespan, but shortens chronological lifespan [11361336]. | Budding yeast |
RAD27 | — | Deletion of RAD27 results in signs of premature aging and approximately 60% reduction in mean replicative lifespan [12024027]. | Budding yeast |
SUN4 | — | Disruption of SUN4 shortens mean (87.5% of normal), but not maximum, replicative lifespan in BKY1-14c [Austriaco, N.R. (1996) âUTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae.â Ph.D. Thesis, Massachusetts Institute of Technology; 8810036]
SUN4 mutation causes failure of daughter cells to completely detach and results in a multi-budded morphology [10683261]. | Budding yeast |
W09C5.8 | — | RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434].
W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
him-6 | — | him-6 mutants have a low brood size, a shortened lifespan, and an increased amount of germ-line apoptosis [16181657]. | Nematode |
YBR225W | — | Deletion of YBR225W decreases replicative lifespan by 40% in the alpha strain [19030232]. | Budding yeast |
RRG1 | — | Deletion of RRG1 decreases replicative lifespan by 50% in the alpha strain [19030232]. | Budding yeast |
YDR089W | — | Deletion of YDR089W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
YDR132C | — | Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. | Budding yeast |
YDR262W | — | Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
YGR071C | — | Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. | Budding yeast |
ANS1 | — | Deletion of ANS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. | Budding yeast |
YKL069W | — | Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. | Budding yeast |
YLR460C | — | Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. | Budding yeast |
YMR166C | — | Deletion of YMR166C decreases replicative lifespan by 20% in the alpha strain [18340043]. | Budding yeast |
YNR066C | — | Deletion of YNR066C decrease replicative lifespan by 50% in the alpha strain [19030232]. | Budding yeast |
YPR011C | — | Deletion of YPR011V decreases replicative lifespan by 20% in the a strain [18340043]. | Budding yeast |
ESA1 | — | esa1-531 mutant has an even shorter chronological lifespan than PKA1 deletion mutant in both 2% glucose (ad libitum) and water (extreme DR) at 30 degree Celsius, a semipermissive temperature. At the permissive temperature (25 degree Celsius) there is little difference [19303850]. | Budding yeast |
CYT2 | — | Mutation of CYT2 decreases replicative lifespan by 25% in the alpha strain [18340043; 19030232].
| Budding yeast |
phi-50 | — | RNA interference of phi-50 decreases mean lifespan by 29% and suppresses lifespan extension by isp-1 and eat-2 mutation but does not significantly affect lifespan extension by daf-2 [22829775]. | Nematode |
C01F1.1 | — | RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. | Nematode |
C06A5.1 | — | RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. | Nematode |