| C18E9.10 | — | RNA interference of C18E9.10 results in lifespan extension [15998808]. | Nematode |
| C26B2.2 | — | C26B2.2 knockout mutations extend lifespan [15253933]. | Nematode |
| C27B7.7 | — | RNA interference of C27B7.7 extends lifespan [15998808]. | Nematode |
| C32H11.1 | — | RNA interference of C32H11.1 extends lifespan [12845331]. | Nematode |
| C32H11.5 | — | RNA interference of C32H11.5 extends lifespan [15998808]. | Nematode |
| C33A12.1 | — | RNA interference of C33A12.1 increase mean lifespan by 40% [17608836]. | Nematode |
| C33F10.12 | — | RNA interference of C33H5.18 extends lifespan [15998808]. | Nematode |
| C35A11.3 | — | RNA interference of C35A11.3 extends lifespan [15998808]. | Nematode |
| C36H8.1 | — | RNA interference of C36H8.1 extends lifespan [15998808]. | Nematode |
| C42C1.3 | — | RNA interferenceof C42C1.3 increases mean lifespan by 60% [17608836]. | Nematode |
| C46G7.2 | — | RNA interference of C46G7.2 increases mean lifespan by 44% [17608836]. | Nematode |
| C47E12.2 | — | RNA interference of C47E12.2 increases mean lifespan by 36% [17608836]. | Nematode |
| C48E7.2 | — | RNA interference of C48E7.2 in adulthood results in a 26% increase in mean lifespan [17521386]. | Nematode |
| C56G2.1 | — | RNA interference of C56G2.1 in adulthood results in a 20% increase in mean lifespan [17411345]. | Nematode |
| R02D3.3 | — | R02D3.3 RNAi in the adulthood extends mean and maximum lifespan by 13 and 22%, respectively [23144747]. | Nematode |
| mir-239 | — | Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively, whereas overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Nematode |
| mrps-5 | — | Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. | Nematode |
| mrpl-1 | — | Knockdown of mrpl-1 increases lifespan by 57% [23698443]. | Nematode |
| mrpl-2 | — | Knockdown of mrpl-2 increases lifespan by 54% [23698443]. | Nematode |
| mrpl-37 | — | Knockdown of mrpl-37 increases lifespan by 41% [23698443]. | Nematode |
| rps-27 | Ribosomal Protein, Small subunit | Knockdown of rps-27 by RNAi extends mean and maximum lifespan by 50 and 44%, respectively [19293945]. | Nematode |
| shc-1 | SHC (Src Homology domain C-terminal) adaptor homolog | Loss of shc-1 function results in accelerated aging and enhanced senstivity ro heat, oxidative stress and heavy metals. | Nematode |
| cid-1 | (Caffeine Induced Death (S. pombe Cid) homolog 1 | RNA interference of cid-1 extends lifespan results in developmental abnormalities but also a significant increase in lifespan [16741121]. | Nematode |
| hpd-1 | 4-HydroxyPhenylpyruvate Dioxygenase (HPD)) 1 | RNAi knockdown of hpd-1 starting at hatching or only during the adulthood significantly extends lifespan of both wild-type and eat-2 [22810224]. | Nematode |
| abcx-1 | ABC transporter, eXtended 1 | RNA interferenceof abcx-1 in adulthood extends mean lifespan by 16% [17521386]. | Nematode |
