Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Nematode (6)   Fruit fly (24)  
  • Classifications: + -
    Gerontogene «  Aging‑Suppressor (2)   Negative Aging‑Suppressor (2)   Positive Aging‑Suppressor (1)   Negative Gerontogene (6)   Positive Gerontogene (24)   DR‑Essential (4)  
  • Types: + -
    Protein coding «  Gene (30)  
    • symbol name observation species
    snz snazarus Mutation in snz increases maximum lifespan of both sexes by up to 66%, while the median female lifespan is approximately 85% higher and that of males around 72% [18478054]. Fruit fly
    sun Stunted sun mutations increases lifespan and resistance to oxidative stress [15133470] Fruit fly
    sdhC succinate dehydrogenase, cytochrome b556 subunit Mutants expressing a dominant negative form of sdhC in the nervous system have a 22% reduced mean lifespan and signs of oxidative stress induction [17854771]. Fruit fly
    Surf1 surfeit gene 1 Surf1 knockdown results in larval lethality. However, knockdown in the central nervous system (CNS) not only bypasses the larval lethality but it results in an increase in maximum lifespan of about 20-30% [16172499]. Fruit fly
    ttll-9 Tubulin Tyrosine Ligase Like Knockdown of ttll-9 throughout the entire life increases the lifespan by 3% [23698443]. Nematode
    Factors are an extension of GenAge and GenDR.

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