F18F11.1 | — | F18F11.1 knockdown extends mean lifespan by 17% and 11%, respectively [22509016]. | Nematode |
R03D7.4 | — | RNAi against R03D7.4 increases mean and maximum lifespan by 9-17% and 7%, respectively [18059442]. | Nematode |
F13G3.7 | — | RNAi against F13G3.7 increases mean and maximum lifespan by 25% and 50%, respectively. Lifespan extension by F13G3.7 RNAi is dependent on daf-16 [12447374]. | Nematode |
B0035.12 | — | RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. | Nematode |
E01A2.2 | — | RNAi against E01A2.2 increases mean and maximum lifespan by 11 and 18%, respectively [19293945]. | Nematode |
F13G3.10 | — | RNAi of F13G3.10 extends mean and maximum lifespan by 11 and 14%, respectively [19293945]. | Nematode |
Y56A3A.9 | — | Y56A3A.9 RNA interference extends lifespan. | Nematode |
C18E9.4 | — | RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. | Nematode |
F35D2.3 | — | RNAi of F35D2.3 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
F40F8.5 | — | RNAi of F40F8.5 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. | Nematode |
T09A5.8 | — | RNAi of cec-3 starting at L1 extends mean and 25%ile lifespan by 3 and 8% [15998808]. | Nematode |
mecr-1 | — | RNAi of mecr-1 extends mean, median and 25%ile lifespan by 6, 8 and 8% [15998808]. | Nematode |
D2030.4 | — | RNAi against D2030.4 prolongs mean and maximum lifespan by 43% and 50%, respectively. Lifespan extension by RNAi of D2030.4 is not suppressed by daf-16. D2030.4 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
F26E4.6 | — | F26E4.6 RNA interference extends mean and maximum lifespan by about 48% and 50%, respectively. Lifespan extension by F26E4.6 RNAi is not suppressed by daf-16. F26E4.6 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
F28B3.5 | — | RNA interference of F28B3.5 extends mean lifespan by 31% and 55%, respectively, and does not cause any developmental pleiotropies nor defects in mitochondrial morphology. Lifespan extension by F28B3.5 is suppressed by daf-16. F28B3.5 animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
F57B10.3 | — | RNA interference against F57B10.3 extends mean and maximum lifespan by 21% and 48%, respectively, without causing any developmental pleiotropies or defects in mitochondrial morphology. Lifespan extension by F57B10.3 is suppressed by daf-16. F57B10.3 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
K01C8.7 | — | K01C8.7 RNAi increases mean and maximum lifespan by 20% and 21%, respectively. Lifespan extension by RNAi of K01C8.7 is not suppressed by daf-16. K01C8.7 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
phi-44 | — | phi-44 RNAi leads to 46% mean and 50% maximum lifespan extension. Lifespan extension by phi-44 is not suppressed by daf-16.
phi-44 RNAi animals have lower ATP content and oxygene consumption [12447374]. | Nematode |
W09C5.8 | — | RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434].
W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374]. | Nematode |
B0511.6 | — | RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. | Nematode |
ttr-5 | — | RNA interference of ttr-5 increase mean lifespan 14% [17608836]. | Nematode |
tkt-1 | — | RNA interference of tkt-1 increases mean lifespan by 25% [17608836]. | Nematode |
age-2 | — | Homocygous age-2 mutation increases mean (+43%, +31%, +38%) and maximum (+29%, +36%, +18%)) lifespan by about 20%. age-2 mutant exhibit normal motility, slightly higher swimming rates, reduced fertility and somewhat longer development times and slightly larger size at the first egg laying. Lifespan is extended by reducing the initial mortality rate. age-2 mutation complements other aging gene mutations such as age-1, daf-2, spe-26, clk-1, clk-3 and gro-1. A age-1 age-2 double mutant lives longer than animals with individual mutations and exhibits a longer lifespan at 25 degree Celsius than at 20 degree Celsius [10219000]. | Nematode |
B0491.5 | — | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Nematode |
B0546.3 | — | RNA interference of B0546.3 increases mean lifespan by 27% [17608836]. | Nematode |