Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    gsa-1 RNAi against R06A10.2 decreases mean and maximum lifespan by 83-85% and 48%, respectively [18059442]. Nematode
    Y47D3A RNAi against Y47D3A.29 decreases mean and maximum lifespan by 19-26% and 34% [18059442]. Nematode
    pas-1 RNAi against pas-1 started after the animal reached the late L4 stage decreases mean lifespan by 18-19% [22103665]. RNAi pas-1 decreases lifespan of daf-2 mutant, but not of WT or glp-1 mutant [17392428]. Nematode
    HSC80 Deletion of HSC82 has no effect on replicative lifespan, but shortens chronological lifespan [11361336]. Budding yeast
    RAD27 Deletion of RAD27 results in signs of premature aging and approximately 60% reduction in mean replicative lifespan [12024027]. Budding yeast
    SUN4 Disruption of SUN4 shortens mean (87.5% of normal), but not maximum, replicative lifespan in BKY1-14c [Austriaco, N.R. (1996) “UTH1 and the Genetic Control of Aging in the Yeast, Saccharomyces cerevisiae.” Ph.D. Thesis, Massachusetts Institute of Technology; 8810036] SUN4 mutation causes failure of daughter cells to completely detach and results in a multi-budded morphology [10683261]. Budding yeast
    W09C5.8 RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434]. W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    him-6 him-6 mutants have a low brood size, a shortened lifespan, and an increased amount of germ-line apoptosis [16181657]. Nematode
    YBR225W Deletion of YBR225W decreases replicative lifespan by 40% in the alpha strain [19030232]. Budding yeast
    RRG1 Deletion of RRG1 decreases replicative lifespan by 50% in the alpha strain [19030232]. Budding yeast
    YDR089W Deletion of YDR089W decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YDR132C Deletion of YDR132C decreases replicative lifespan by 35% in the alpha strain [19030232]. Budding yeast
    YDR262W Deletion of YDR262W decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YGR071C Deletion of YGR071C decreases replicative lifespan by 60% in the alpha strain [19030232]. Budding yeast
    ANS1 Deletion of ANS1 decreases replicative lifespan by 25% in the alpha strain [19030232]. Budding yeast
    YKL069W Deletion of YKL069W increases sensitivity to oxidative stress and decreases replicative lifespan [19049972]. Budding yeast
    YLR460C Deletion of YLR460C decreases replicative lifespan by 30% in the alpha strain [19030232]. Budding yeast
    YMR166C Deletion of YMR166C decreases replicative lifespan by 20% in the alpha strain [18340043]. Budding yeast
    YNR066C Deletion of YNR066C decrease replicative lifespan by 50% in the alpha strain [19030232]. Budding yeast
    YPR011C Deletion of YPR011V decreases replicative lifespan by 20% in the a strain [18340043]. Budding yeast
    ESA1 esa1-531 mutant has an even shorter chronological lifespan than PKA1 deletion mutant in both 2% glucose (ad libitum) and water (extreme DR) at 30 degree Celsius, a semipermissive temperature. At the permissive temperature (25 degree Celsius) there is little difference [19303850]. Budding yeast
    CYT2 Mutation of CYT2 decreases replicative lifespan by 25% in the alpha strain [18340043; 19030232]. Budding yeast
    phi-50 RNA interference of phi-50 decreases mean lifespan by 29% and suppresses lifespan extension by isp-1 and eat-2 mutation but does not significantly affect lifespan extension by daf-2 [22829775]. Nematode
    C01F1.1 RNA interference of C01F1.1 decreases median lifespan by 28% in wild-type animals, 37% in a daf-2 background and 14% in daf-2/daf-16 double mutants [18006689]. Nematode
    C06A5.1 RNA interference of C06A5.1 decreases median lifespan by 39% in wild type animals, 24% in a daf-2 background and 71% in daf-2/daf-16 double mutants [18006689]. Nematode
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    • 25 of 321 factors
    Factors are an extension of GenAge and GenDR.

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