Doc3 | Dorsocross3 | Doc3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
Gain-of-function mutation in Doc3 causes delay of age-related motor impairment [19481596].
| Fruit fly |
dro2 | drosomycin-2 | dro2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
dro4 | drosomycin-4 | dro4 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is downregulated in head of animals that were selected for longevity at early and intermediate ages [23106705]. | Fruit fly |
endoA | endophilin A | endoA exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
fs(1)M3 | female sterile (1) M3 | fs(1)M3 exhibits a coding region difference unique to animals under experimental evolution selected for longevity [23106705].
| Fruit fly |
fry | furry | fry exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in abdomen of animals that were selected for longevity [23106705]. | Fruit fly |
Hsp70Ba | Heat-shock-protein-70Ba | Hsp70Ba overexpression reduces mean and maximum lifespan up to 30% [19420297].
hsp70 and hsp22 RNA levels are higher in long-lived than in short-lived fly lines. The HDAC inhibitor TSA causes a higher expression of hsp22 and hsp70, and strikingly influences the lifespan in both long and short-lived lines, with variable degrees (up to 25%) [15695762]. | Fruit fly |
InR | Insulin-like 1 receptor | Mutations in InR (InRE19/InRp5545 transheterozygous) result in dwarf females with extended lifespan of up to 85% and dwarf males with reduced late age-specific mortality (although no significant change in lifespan) [11292875]. InrGC25/InrE19 transheterozygous animals are short-lived an exhibit an elevated rate of age-independent mortality [11292874].
Natural allelic variation in InR are associated with variation in lifespan [15013662; 20074316]. | Fruit fly |
kst | karst | kst exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it has three differentially expressed transcripts in head of animals that were selected for longevity [23106705]. | Fruit fly |
LanB2 | Laminin B2 | LanB2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
Prm | Paramyosin | Prm exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the abdomen of for longevity selected lines [23106705]. | Fruit fly |
Psa | Puromycin sensitive aminopeptidase | Psa exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and is upregulated in head of animals that were selected for longevity at all ages except 50 days [23106705]. Experimental u-regulation of Psa protects against tau-induced neurodegeneration [16950154]. | Fruit fly |
Rh2 | Rhodopsin 2 | Rh2 exhibits a non-coding region difference unique to animals under experimental evolution selected for longevity and it is differentially expressed in head of animals that were selected for longevity [23106705]. | Fruit fly |
Ten-a | Tenascin accessory | Ten-a exhibits a coding region difference unique to animals under experimental evolution selected for longevity and is differentially expressed in the head in for longevity selected lines [23106705]. | Fruit fly |