Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    D4ACK9_RAT D4ACK9_RAT is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    D3ZTB8_RAT D3ZTB8_RAT is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    ENSRNOG00000044070 is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. Norway rat
    Intergenic Intergenic was found to be associated with longevity [21418511]. Intergenic was found to be associated with longevity [22533364]. Intergenic was found to be associated with longevity [14615589]. Intergenic was found to be associated with longevity [21782286]. Intergenic was found to be associated with longevity [22279548]. Human
    ND2 ND2 was found to be associated with longevity [10996007]. Human
    ATP8 ATP8 was found to be associated with longevity [10996007]. Human
    16S rRNA 16S rRNA was found to be associated with longevity [10996007]. Human
    mtDNA
    Human Indy homolog Human Indy homolog was found to be associated with longevity [14499494]. Human
    3p22-24 region 3p22-24 region was found to be associated with longevity [22506048]. Human
    HSP70-A1A HSP70-A1A was found to be associated with longevity [17027907]. Human
    HSP70-A1B HSP70-A1B was found to be associated with longevity [17027907]. Human
    mtDNA haplogroups mtDNA haplogroups was found to be associated with longevity [18545700]. Human
    Insulin signaling pathway (IIS) Insulin signaling pathway (IIS) was found to be associated with longevity [22113349]. Human
    Telomere maintenance pathway (TM) Telomere maintenance pathway (TM) was found to be associated with longevity [22113349]. Human
    Chromosome 4 at D4S1564 Chromosome 4 at D4S1564 was found to be associated with longevity [11526246]. Human
    mtDNA haplogroup mtDNA haplogroup was found to be associated with longevity [18759861]. Human
    3p24-22 3p24-22 was found to be associated with longevity [20824210]. Human
    mtDNA L2 mtDNA L2 was found to be associated with longevity [21262335]. Human
    6q25-27 region 6q25-27 region was found to be associated with longevity [22773346]. Human
    MT-ND5 MT-ND5 was found to be associated with longevity [18759861]. Human
    Intergenic (downstream of SSBP3 and MRPL37) Intergenic (downstream of SSBP3 and MRPL37) was found to be associated with longevity [21418511]. Human
    Noncoding Noncoding was found to be associated with longevity [22533364]. Human
    AC000050.2 AC000050.2 was found to be associated with longevity [22533364]. Human
    Intergenic (upstream of C4orf17) Intergenic (upstream of C4orf17) was found to be associated with longevity [14615589]. Human
    Factors are an extension of GenAge and GenDR.

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