| Vitamin C | — | Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].
Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628]. | Nematode |
| vit-1 | Vitellogenin-1 | vit-1 RNAi animals have a mean lifespan that 103.3% of controls, but not significant different. vit-1 is differentially expressed in daf-16 and daf-2 RNAi animals [12845331]. | Nematode |
| unc-80 | UNCoordinated | The unc-80(e1069) allele has no significant effect on lifespan [9789046].
unc-80 mutant displays irregular movement [4366476] | Nematode |
| unc-79 | UNCoordinated | The unc-79(e1068) allele has no significant effect on lifespan [9789046].
unc-78 mutants display irregular movement [4366476]. | Nematode |
| unc-78 | UNCoordinated 78 | Mutation in unc-78 has no effect on lifespan [9789046].
unc-78 mutants move slowly [7190524]. | Nematode |
| unc-7 | UNCoordinated | Mutation of unc-7 has no effect on lifespan [9789046].
unc-67 mutants are uncoordinated [4366476]. | Nematode |
| unc-6 | UNCoordinated 6 | Mutation in unc-6 has no effect on lifespan [9789046].
unc-6 mutants are uncoordinated [4366476]. | Nematode |
| unc-54 | UNCoordinated 54 | Mutation in unc-54 has no effect on lifespan [9789046].
unc-54 mutants are paralyzed [4366476]. | Nematode |
| unc-52 | UNCoordinated 52 | RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. | Nematode |
| unc-49 | UNCoordinated 49 | The unc-49(e382) allele has no significant effect on lifespan [9789046].
unc-49 mutants are uncoordinated [4366476]. | Nematode |
| unc-47 | UNCoordinated 47 | The unc-47(e367) allele has no significant effect on lifespan [9789046].
unc-47 mutants are uncoordinated [4366476]. | Nematode |
| unc-46 | UNCoordinated 46 | unc-46(e177) allele has no significant effect on lifespan [9789046].
unc-46 mutants are uncoordinated [4366476]. | Nematode |
| unc-30 | UNCoordinated 30 | Mutations in unc-30 have no significant effect on lifespan [9789046].
unc-30 mutants are uncoordinated [4366476]. | Nematode |
| unc-29 | UNCoordinated | Mutation in unc-29 has no effect on lifespan [9789046] and fails to extend male lifespan [10747056].
unc-29 mutants are uncoordinated [4366476]. | Nematode |
| unc-25 | UNCoordinated 25 | Mutations in unc-25 have no effect on lifespan [9789046].
unc-25 mutants are defective for foraging, locomotion, and defecation [8332190] as well as uncoordinated [4366476]. | Nematode |
| unc-24 | UNCordinated 24 | Mutations in unc-24 have no significant effect on lifespan [9789046] and unc-24(e138) fails to extend male lifespan [10747056].
unc-24 mutant is uncoordinated and displays irregular movement [4366476; 8667025]. | Nematode |
| unc-2 | UNCoordinated 2 | Loss of function in unc-2 has no effect on lifespan [9789046].
unc-2 mutant is uncoordinated [4366476] and its rate of pharyngeal pumping is reduced [8325482]. | Nematode |
| unc-15 | UNCoordinated 15 | Mutation of unc-15 has no effect on lifespan [9789046]. Some alleles of un-15 display severe paralysis [4366476; 2051482]. | Nematode |
| unc-1 | UNCoordinated 1 | Mutation in unc-1 has no effect on lifespan [9789046]. | Nematode |
| ucp-4 | UnCoupling Protein (mitochondrial substrate carrier) family member (ucp-4) | Overexpression reduces mean lifespan by 5%, has no significant effect on median lifespan, and slighlty increases maximum lifespan by 12% [22737090]. | Nematode |
| uba-1 | UBA (human ubiquitin) related | Overexpression of uba-1 does not result in significant increase in median lifespan [22737090]. | Nematode |
| tax-2 | abnormal CHEmotaxis | Loss of function mutation in tax-2 has no effect on lifespan [10617200].
tax-2 mutants are defective in chemotaxis, thermotaxis, odorant defect and have some dye-filling defects [8893026] as well as are exhibit some defects in dauer formation [10064800]. | Nematode |
| spg-7 | human SPG (spastic paraplegia) 7 | RNA interference of spg-7 in adulthood results in a 23% increase in mean lifespan [17411345]. | Nematode |
| sir-2.4 | yeast SIR related 2.4 | RNA interference against sir-2.4 or overexpression of SIR-2.4 do not change the mean or maximum lifespan. Neither sir-2.4 RNAi nor SIR-2.4 overexpression affects the increased lifespan of daf-2(e1370) mutants [Tishkoff et al. 2012]. | Nematode |
| sip-1 | Stress Induced Protein 1 | RNAi of sip-1 has no effect on wild-type adult lifespan, but slightly shortens the long lifespan of age-1(hx546) mutant animals [14668486]. | Nematode |
